The Circadian Protein Period2 Suppresses mTORC1 Activity via Recruiting Tsc1 to mTORC1 Complex
文献类型：期刊论文
| 作者 | Chen, Yaqiong1; Liu, Yi1; Wu, Rong2; Dang, Fabin2; Li, Peng2; Wang, Pengfei2; Liu, Zhengshuai2; Li, Yu2; Wu, Yuting2; Xu, Qian3 |
| 刊名 | CELL METABOLISM
 |
| 出版日期 | 2019 |
| 卷号 | 29期号:3页码:653-+ |
| ISSN号 | 1550-4131 |
| DOI | 10.1016/j.cmet.2018.11.006 |
| 文献子类 | Article |
| 英文摘要 | Although emerging evidence indicates an important role of the circadian clock in modulating the diurnal oscillation of mammalian target of rapamycin complex 1 (mTORC1) signaling, the underlying molecular mechanism remains elusive. Here we show that Period2 (Per2), a core clock protein, functions as a scaffold protein to tether tuberous sclerosis complex 1 (Tsc1), Raptor, and mTOR together to specifically suppress the activity of mTORC1 complex. Due to the loss of its inhibition of mTORC1, Per2 deficiency significantly enhances protein synthesis and cell proliferation but reduces autophagy. Furthermore, we find that the glucagon-Creb/Crtc2 signaling cascade induces Per2 expression, which mediates the suppression of mTORC1 in mouse liver during fasting. Our study not only uncovers a novel role of Per2 in regulating the mTORC1 pathway, but also sheds new light on the mechanism of fasting inhibition on mTORC1 in the liver. |
| 学科主题 | Cell Biology ; Endocrinology & Metabolism |
| WOS关键词 | CELL-GROWTH ; DEREGULATED EXPRESSION ; LIPID-METABOLISM ; MODULATES GLUCONEOGENESIS ; TSC1-TSC2 COMPLEX ; DIRECT TARGET ; RAG GTPASES ; CLOCK ; GENE ; PER2 |
| 语种 | 英语 |
| WOS记录号 | WOS:000460276900013 |
| 出版者 | CELL PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/490]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Fudan Univ, Key Lab Metab & Mol Med, Minist Educ, Dept Biochem & Mol Biol,Sch Basic Med Sci, Shanghai 200032, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Univ Chinese Acad Sci, CAS Key Lab Nutr Metab & Food Safety,Shanghai Ins, Shanghai 200031, Peoples R China; 3.Harbin Med Univ, Dept Endocrinol, Affiliated Hosp 1, 23 Youzheng St, Harbin 150081, Heilongjiang, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Chen, Yaqiong,Liu, Yi,Wu, Rong,et al. The Circadian Protein Period2 Suppresses mTORC1 Activity via Recruiting Tsc1 to mTORC1 Complex[J]. CELL METABOLISM,2019,29(3):653-+. |
| APA | Chen, Yaqiong.,Liu, Yi.,Wu, Rong.,Dang, Fabin.,Li, Peng.,...&Xu, Qian.(2019).The Circadian Protein Period2 Suppresses mTORC1 Activity via Recruiting Tsc1 to mTORC1 Complex.CELL METABOLISM,29(3),653-+. |
| MLA | Chen, Yaqiong,et al."The Circadian Protein Period2 Suppresses mTORC1 Activity via Recruiting Tsc1 to mTORC1 Complex".CELL METABOLISM 29.3(2019):653-+. |
入库方式： OAI收割
来源：上海营养与健康研究所
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