Lineage Tracing Reveals the Bipotency of SOX9(+) Hepatocytes during Liver Regeneration
文献类型：期刊论文
| 作者 | Han, Ximeng7,8,10; Wang, Yue7,10; Pu, Wenjuan7,10; Huang, Xiuzhen7,10; Li, Yan7,10; Yu, Wei7,10; Zhao, Huan7,10; Liu, Xiuxiu10; He, Lingjuan7,10; Zhang, Libo7,10 |
| 刊名 | STEM CELL REPORTS
 |
| 出版日期 | 2019 |
| 卷号 | 12期号:3页码:624-638 |
| ISSN号 | 2213-6711 |
| DOI | 10.1016/j.stemcr.2019.01.010 |
| 文献子类 | Article |
| 英文摘要 | Elucidation of the role of different cell lineages in the liver could offer avenues to drive liver regeneration. Previous studies showed that SOX9(+) hepatocytes can differentiate into ductal cells after liver injuries. It is unclear whether SOX9(+) hepatocytes are uni- or bipotent progenitors at a single-cell level during liver injury. Here, we developed a genetic tracing system to delineate the lineage potential of SOX9(+) hepatocytes during liver homeostasis and regeneration. Fate-mapping data showed that these SOX9(+) hepatocytes respond specifically to different liver injuries, with some contributing to a substantial number of ductal cells. Clonal analysis demonstrated that a single SOX9(+) hepatocyte gives rise to both hepatocytes and ductal cells after liver injury. This study provides direct evidence that SOX9(+) hepatocytes can serve as bipotent progenitors after liver injury, producing both hepatocytes and ductal cells for liver repair and regeneration. |
| 学科主题 | Cell Biology |
| WOS关键词 | PROGENITOR CELLS ; STEM-CELLS ; HOMEOSTASIS ; ORIGIN ; INJURY ; TRANSDIFFERENTIATION ; MODEL ; RISE ; RAT |
| 语种 | 英语 |
| WOS记录号 | WOS:000460407800016 |
| 出版者 | CELL PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/491]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Nanjing Med Univ, Key Lab Cardiovasc & Cerebrovasc Med, Nanjing 211100, Jiangsu, Peoples R China; 2.Tongji Univ, Sch Med, Dept Gastroenterol, Shanghai Peoples Hosp 10, Shanghai 200072, Peoples R China; 3.Chinese Univ Hong Kong, Dept Chem Pathol, Prince Wales Hosp, Shatin, Hong Kong 999077, Peoples R China; 4.Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Prince Wales Hosp, Shatin, Hong Kong 999077, Peoples R China; 5.Jinan Univ, Minist Educ, Key Lab Regenerat Med, Inst Aging & Regenerat Med, Guangzhou 510632, Guangdong, Peoples R China; 6.Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China, 7.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr & Hlth, Shanghai 200031, Peoples R China; 8.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; 9.Nanjing Med Univ, Collaborat Innovat Ctr Cardiovasc Dis Translat Me, Nanjing 211100, Jiangsu, Peoples R China; 10.Univ Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, State Key Lab Cell Biol, Shanghai Inst Biochem & Cell Biol,Chinese Acad Sc, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Han, Ximeng,Wang, Yue,Pu, Wenjuan,et al. Lineage Tracing Reveals the Bipotency of SOX9(+) Hepatocytes during Liver Regeneration[J]. STEM CELL REPORTS,2019,12(3):624-638. |
| APA | Han, Ximeng.,Wang, Yue.,Pu, Wenjuan.,Huang, Xiuzhen.,Li, Yan.,...&,.(2019).Lineage Tracing Reveals the Bipotency of SOX9(+) Hepatocytes during Liver Regeneration.STEM CELL REPORTS,12(3),624-638. |
| MLA | Han, Ximeng,et al."Lineage Tracing Reveals the Bipotency of SOX9(+) Hepatocytes during Liver Regeneration".STEM CELL REPORTS 12.3(2019):624-638. |
入库方式： OAI收割
来源：上海营养与健康研究所
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