Recently Evolved Tumor Suppressor Transcript TP73-AS1 Functions as Sponge of Human-Specific miR-941
文献类型：期刊论文
| 作者 | Hu, Haiyang3,4; Jiang, Xi4; Yang, Xiaode4; Liu, Jian-Mei5,7; Hu, Zhenyu5,7; Li, Jiangxia5,7; Zhang, Yao5,7; Yu, Haijing5,7; Yang, Xiaode6; Khaitovich, Philipp1,2,8,9,10 |
| 刊名 | MOLECULAR BIOLOGY AND EVOLUTION
 |
| 出版日期 | 2018 |
| 卷号 | 35期号:5页码:1063-1077 |
| ISSN号 | 0737-4038 |
| 关键词 | microRNA sponge young noncoding RNA co-evolution tumorigenesis |
| DOI | 10.1093/molbev/msy022 |
| 文献子类 | Article |
| 英文摘要 | MicroRNA (miRNA) sponges are vital components of posttranscriptional gene regulation. Yet, only a limited number of miRNA sponges have been identified. Here, we show that the recently evolved noncoding tumor suppressor transcript, antisense RNA to TP73 gene (TP73-AS1), functions as a natural sponge of human-specific miRNA miR-941. We find unusually nine high-affinity miR-941 binding sites clustering within 1 kb region on TP73-AS1, which forms miR-941 sponge region. This sponge region displays increased sequence constraint only in humans, and its formation can be traced to the tandem expansion of a 71-nt-long sequence containing a single miR-941 binding site in old world monkeys. We further confirm TP73-AS1 functions as an efficient miR-941 sponge based on massive transcriptome data analyses, wound-healing assay, and Argonaute protein immunoprecipitation experiments conducted in cell lines. The expression of miR-941 and its sponge correlate inversely across multiple healthy and cancerous tissues, with miR-941 being highly expressed in tumors and preferentially repressing tumor suppressors. Thus, the TP73-AS1 and miR-941 duo represents an unusual case of the extremely rapid evolution of noncoding regulators controlling cell migration, proliferation, and tumorigenesis. |
| 学科主题 | Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity |
| WOS关键词 | LONG NONCODING RNAS ; MICRORNA TARGET SITES ; NONHUMAN-PRIMATES ; MULTIPLE-MYELOMA ; GENE-EXPRESSION ; MESSENGER-RNAS ; GENOME BROWSER ; CIRCULAR RNAS ; CANCER ; EVOLUTION |
| 语种 | 英语 |
| 出版者 | OXFORD UNIV PRESS |
| WOS记录号 | WOS:000431889600003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/496]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China, 2.Skolkovo Inst Sci & Technol, Skolkovo, Russia; 3.China Pharmaceut Univ, Sch Life Sci & Technol, Nanjing, Jiangsu, Peoples R China; 4.CAS MPG Partner Inst Computat Biol, CAS Key Lab Computat Biol, Shanghai, Peoples R China; 5.Yunnan Univ, Sch Life Sci, State Key Lab Nat Resource Conservat & Utilizat, Kunming, Yunnan, Peoples R China; 6.Univ Chinese Acad Sci, Beijing, Peoples R China; 7.Yunnan Univ, Sch Life Sci, Ctr Life Sci, Kunming, Yunnan, Peoples R China; 8.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming, Yunnan, Peoples R China; 9.CAS MPG Partner Inst Computat Biol, Comparat Biol Grp, Shanghai, Peoples R China; 10.Max Planck Inst Evolutionary Anthropol, Leipzig, Germany; |
| 推荐引用方式 GB/T 7714 | Hu, Haiyang,Jiang, Xi,Yang, Xiaode,et al. Recently Evolved Tumor Suppressor Transcript TP73-AS1 Functions as Sponge of Human-Specific miR-941[J]. MOLECULAR BIOLOGY AND EVOLUTION,2018,35(5):1063-1077. |
| APA | Hu, Haiyang.,Jiang, Xi.,Yang, Xiaode.,Liu, Jian-Mei.,Hu, Zhenyu.,...&,.(2018).Recently Evolved Tumor Suppressor Transcript TP73-AS1 Functions as Sponge of Human-Specific miR-941.MOLECULAR BIOLOGY AND EVOLUTION,35(5),1063-1077. |
| MLA | Hu, Haiyang,et al."Recently Evolved Tumor Suppressor Transcript TP73-AS1 Functions as Sponge of Human-Specific miR-941".MOLECULAR BIOLOGY AND EVOLUTION 35.5(2018):1063-1077. |
入库方式： OAI收割
来源：上海营养与健康研究所
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