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Reconstruction of kidney renal clear cell carcinoma evolution across pathological stages

文献类型：期刊论文

作者Pang, Shichao5; Wu, Leilei6; Zhao, Yi-Lei6; Li, Yixue1,4,6,7; Sun, Yidi1,4,7; Yang, Liguang1,4; Wang, Zhen4; Li, Yixue2,3; ,
刊名SCIENTIFIC REPORTS
出版日期2018
卷号8期号:-页码:3339
关键词calcium silicate chitosan cardiac patch bioactive ions aligned nanostructure
ISSN号2045-2322
DOI10.1038/s41598-018-20321-4
文献子类Article
英文摘要Although numerous studies on kidney renal clear cell carcinoma (KIRC) were carried out, the dynamic process of tumor formation was not clear yet. Inadequate attention was paid on the evolutionary paths among somatic mutations and their clinical implications. As the tumor initiation and evolution of KIRC were primarily associated with SNVs, we reconstructed an evolutionary process of KIRC using cross-sectional SNVs in different pathological stages. KIRC driver genes appeared early in the evolutionary tree, and the genes with moderate mutation frequency showed a pattern of stage-by-stage expansion. Although the individual gene mutations were not necessarily associated with survival outcome, the evolutionary paths such as VHL-PBRM1 and FMN2-PCLO could indicate stage-specific prognosis. Our results suggested that, besides mutation frequency, the evolutionary relationship among the mutated genes could facilitate to identify novel drivers and biomarkers for clinical utility.
学科主题Science & Technology - Other Topics
WOS关键词CANCER SYSTEMS BIOLOGY ; SOMATIC EVOLUTION ; CLONAL EVOLUTION ; TUMOR EVOLUTION ; GENOME ATLAS ; DIFFERENTIATION ; WEBGESTALT ; REGULATORS ; SIGNATURES ; NETWORKS
语种英语
WOS记录号WOS:000425500300011
出版者NATURE PUBLISHING GROUP
版本出版稿
源URL[http://202.127.25.144/handle/331004/500]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Univ Chinese Acad Sci, Shanghai 200031, Peoples R China;
2.Fudan Univ, Collaborat Innovat Ctr Genet & Dev, Shanghai, Peoples R China,
3.Shanghai Ind Technol Inst, Shanghai Ctr Bioinformat Technol, Shanghai, Peoples R China;
4.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai, Peoples R China;
5.Shanghai Jiao Tong Univ, Sch Math Sci, Dept Stat, Shanghai 200240, Peoples R China;
6.Shanghai Jiao Tong Univ, Dept Bioinformat & Biostat, Joint Int Res Lab Metab & Dev Sci,MOE LSB & LSC, Sch Life Sci & Biotechnol,State Key Lab Microbial, Shanghai 200240, Peoples R China;
7.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, CAS Key Lab Syst Biol,CAS Ctr Excellence Mol Cell, 320 YueYang Rd, Shanghai 200031, Peoples R China;
推荐引用方式
GB/T 7714		 Pang, Shichao,Wu, Leilei,Zhao, Yi-Lei,et al. Reconstruction of kidney renal clear cell carcinoma evolution across pathological stages[J]. SCIENTIFIC REPORTS,2018,8(-):3339.
APA Pang, Shichao.,Wu, Leilei.,Zhao, Yi-Lei.,Li, Yixue.,Sun, Yidi.,...&,.(2018).Reconstruction of kidney renal clear cell carcinoma evolution across pathological stages.SCIENTIFIC REPORTS,8(-),3339.
MLA Pang, Shichao,et al."Reconstruction of kidney renal clear cell carcinoma evolution across pathological stages".SCIENTIFIC REPORTS 8.-(2018):3339.

入库方式： OAI收割

来源：上海营养与健康研究所

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