Functions and Regeneration of Mature Cardiac Lymphatic Vessels in Atherosclerosis, Myocardial Infarction, and Heart Failure
文献类型：期刊论文
| 作者 | Zhang, Yaqi3; Bai, Yingnan3; Qian, Juying3; Jing, Qing1,2; , |
| 刊名 | LYMPHATIC RESEARCH AND BIOLOGY
 |
| 出版日期 | 2018 |
| 卷号 | 16期号:6页码:507-515 |
| 关键词 | cardiac lymphatic vessels atherosclerosis myocardial infarction heart failure lymphangiogenesis |
| ISSN号 | 1539-6851 |
| DOI | 10.1089/lrb.2018.0023 |
| 文献子类 | Review; Early Access |
| 英文摘要 | Cardiac lymphatic vessels play a vital role in maintaining cardiac homeostasis both under physiological and pathological conditions. Clearer illustration of the anatomy of cardiac lymphatics has been achieved by fluorescence exhibition comparing to dye injection. Besides, identification of specific lymphatic markers in recent decades paves the way for researches in development and regeneration of cardiac lymphatics, such as VEGF-C/VEGFR-3, EphB4/ephrin-B2, Prox-1, Podoplanin, and Lyve-1. Knocking out each of these markers in mice model also reveals the signaling pathways instructing the formation of cardiac lymphatics. In the major cardiovascular disease series of atherosclerosis, myocardial infarction (MI), and heart failure, cardiac lymphatics regulate the transportation of extravasated proteins and lipids, inflammatory and immune responses, as well as fluid balance. Elementary intervention methods, such as lymphatic factor protein injection VEGF-C, are applied in murine MI models to restore or enhance functions of lymphatic vessels, achieving improvements in cardiac function. Also, data from our laboratory showed that intramyocardial EphB4 injection also improved lymphatic regeneration in mouse MI model. Therefore, we believe that enhancing functions and regeneration of mature cardiac lymphatic vessels in cardiovascular diseases is of great potential therapeutic meaning in the future. |
| 学科主题 | Research & Experimental Medicine ; Physiology |
| WOS关键词 | ENDOTHELIAL GROWTH-FACTOR ; REVERSE CHOLESTEROL TRANSPORT ; RECEPTOR KNOCKOUT MICE ; VEGF-C ; LYMPHANGIOGENIC FACTORS ; VASCULAR BIOLOGY ; DENDRITIC CELLS ; TRANSGENIC MICE ; PROX1 FUNCTION ; IMMUNE-SYSTEM |
| 语种 | 英语 |
| WOS记录号 | WOS:000447721100001 |
| 出版者 | MARY ANN LIEBERT, INC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/501]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China, 2.Chinese Acad Sci, Key Lab Stem Cell Biol, Inst Hlth Sci, Shanghai Inst Biol Sci, Shanghai, Peoples R China; 3.Fudan Univ, Shanghai Inst Cardiovasc Dis, Zhongshan Hosp, Dept Cardiol, 180 Fenglin Rd, Shanghai 200032, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Yaqi,Bai, Yingnan,Qian, Juying,et al. Functions and Regeneration of Mature Cardiac Lymphatic Vessels in Atherosclerosis, Myocardial Infarction, and Heart Failure[J]. LYMPHATIC RESEARCH AND BIOLOGY,2018,16(6):507-515. |
| APA | Zhang, Yaqi,Bai, Yingnan,Qian, Juying,Jing, Qing,&,.(2018).Functions and Regeneration of Mature Cardiac Lymphatic Vessels in Atherosclerosis, Myocardial Infarction, and Heart Failure.LYMPHATIC RESEARCH AND BIOLOGY,16(6),507-515. |
| MLA | Zhang, Yaqi,et al."Functions and Regeneration of Mature Cardiac Lymphatic Vessels in Atherosclerosis, Myocardial Infarction, and Heart Failure".LYMPHATIC RESEARCH AND BIOLOGY 16.6(2018):507-515. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。