Perineural invasion is related to p38 mitogen-activated protein kinase pathway activation and promotes tumor growth and chemoresistance in pancreatic cancer
文献类型：期刊论文
| 作者 | Gu, Jiangning1,4,5; Xu, Wei5; Peng, Chenghong4,5; Zhu, Youwei4,5; Zhong, Yiming4,5; Zhao, Shulin5; Cheng, Dongfeng5; Ying, Xiayang5; Jin, Jiabin5; Chen, Hao4,5 |
| 刊名 | JOURNAL OF CELLULAR BIOCHEMISTRY
 |
| 出版日期 | 2019 |
| 卷号 | 120期号:7页码:11775-11783 |
| ISSN号 | 0730-2312 |
| 关键词 | chemoresistance mitogen-activated protein kinase pancreatic cancer perineural invasion |
| DOI | 10.1002/jcb.28457 |
| 文献子类 | Article |
| 英文摘要 | Metastasis is a key component of cancer progression and is strongly associated with poor prognosis. Perineural invasion is thought to be related to pain, tumor recurrence, and other conditions. However, the exact molecular mechanism is unclear. This study was conducted to identify the key components and signaling pathways involved in the perineural invasion of pancreatic cancer and alterations in the phenotype after the interaction between the dorsal root ganglion (DRG) and pancreatic cancer cells. The results indicated that the p38 mitogen-activated protein kinase signaling pathway was activated after coculture of the DRG and pancreatic cancer cells and lead to the promotion of cell growth and chemoresistance. |
| 学科主题 | Biochemistry & Molecular Biology ; Cell Biology |
| WOS关键词 | GEMCITABINE ; THERAPY ; PAIN |
| 语种 | 英语 |
| 出版者 | WILEY |
| WOS记录号 | WOS:000471300600089 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/504]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Dalian Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Dalian, Liaoning, Peoples R China, 2.Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Shanghai Inst Biol Sci, Key Lab Computat Biol,Max Planck Partner Inst Com, Shanghai, Peoples R China; 3.Fudan Univ, Eyes & ENT Hosp, Dept Sci Res, Shanghai, Peoples R China; 4.Shanghai Jiao Tong Univ, Res Inst Digest Surg, Ruijin Hosp, Shanghai, Peoples R China; 5.Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Gen Surg, 197,2nd Ruijin Rd, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Gu, Jiangning,Xu, Wei,Peng, Chenghong,et al. Perineural invasion is related to p38 mitogen-activated protein kinase pathway activation and promotes tumor growth and chemoresistance in pancreatic cancer[J]. JOURNAL OF CELLULAR BIOCHEMISTRY,2019,120(7):11775-11783. |
| APA | Gu, Jiangning.,Xu, Wei.,Peng, Chenghong.,Zhu, Youwei.,Zhong, Yiming.,...&,.(2019).Perineural invasion is related to p38 mitogen-activated protein kinase pathway activation and promotes tumor growth and chemoresistance in pancreatic cancer.JOURNAL OF CELLULAR BIOCHEMISTRY,120(7),11775-11783. |
| MLA | Gu, Jiangning,et al."Perineural invasion is related to p38 mitogen-activated protein kinase pathway activation and promotes tumor growth and chemoresistance in pancreatic cancer".JOURNAL OF CELLULAR BIOCHEMISTRY 120.7(2019):11775-11783. |
入库方式： OAI收割
来源：上海营养与健康研究所
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