Implications of Newly Identified Brain eQTL Genes and Their Interactors in Schizophrenia
文献类型：期刊论文
| 作者 | Cai, Lei2,3,8; Huang, Tao8; Zhang, Xinxin8; Chen, Wenzhong8; He, Lin3,8; Chou, Kuo-Chen2,8; Huang, Tao4; Su, Jingjing5; Zhang, Fuquan6; Chou, Kuo-Chen1,7 |
| 刊名 | MOLECULAR THERAPY-NUCLEIC ACIDS
 |
| 出版日期 | 2018 |
| 卷号 | 12期号:-页码:433-442 |
| 关键词 | GdX/UBL4A NF-kappa B p65/RelA inflammation dendritic cells macrophages |
| ISSN号 | 2162-2531 |
| DOI | 10.1016/j.omtn.2018.05.026 |
| 文献子类 | Article |
| 英文摘要 | Schizophrenia (SCZ) is a devastating genetic mental disorder. Identification of the SCZ risk genes in brains is helpful to understand this disease. Thus, we first used the minimum Redundancy-Maximum Relevance (mRMR) approach to integrate the genome-wide sequence analysis results on SCZ and the expression quantitative trait locus (eQTL) data from ten brain tissues to identify the genes related to SCZ. Second, we adopted the variance inflation factor regression algorithm to identify their interacting genes in brains. Third, using multiple analysis methods, we explored and validated their roles. By means of the aforementioned procedures, we have found that (1) the cerebellum may play a crucial role in the pathogenesis of SCZ and (2) ITIH4 may be utilized as a clinical biomarker for the diagnosis of SCZ. These interesting findings may stimulate novel strategy for developing new drugs against SCZ. It has not escaped our notice that the approach reported here is of use for studying many other genome diseases as well. |
| 学科主题 | Research & Experimental Medicine |
| WOS关键词 | AMINO-ACID-COMPOSITION ; PREDICT SUBCELLULAR-LOCALIZATION ; TUPLE NUCLEOTIDE COMPOSITION ; PHYSICAL-CHEMICAL PROPERTIES ; LYSINE SUCCINYLATION SITES ; HAN CHINESE POPULATION ; ENSEMBLE CLASSIFIER ; RECOMBINATION SPOTS ; BIPOLAR DISORDER ; 2-LAYER PREDICTOR |
| 语种 | 英语 |
| WOS记录号 | WOS:000443860200037 |
| 出版者 | CELL PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/507]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.King Abdulaziz Univ, Fac Comp & Informat Technol Rabigh, Jeddah 21589, Saudi Arabia, 2.Gordon Life Sci Inst, Boston, MA 02478 USA; 3.Shanghai Ctr Women & Childrens Hlth, Shanghai 200062, Peoples R China; 4.Chinese Acad Sci, Inst Hlth Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China; 5.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Neurol, Sch Med, Shanghai 200011, Peoples R China; 6.Nanjing Med Univ, Wuxi Mental Hlth Ctr, Dept Psychiat, Wuxi 214015, Peoples R China; 7.Univ Elect Sci & Technol China, Ctr Informat Biol, Chengdu 610054, Sichuan, Peoples R China; 8.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Collaborat Innovat Ctr Genet & Dev,Bio X Inst, Key Lab Genet Dev & Neuropsychiat Disorders,Minis, 55 Guangyuan Xi Rd, Shanghai 200240, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Cai, Lei,Huang, Tao,Zhang, Xinxin,et al. Implications of Newly Identified Brain eQTL Genes and Their Interactors in Schizophrenia[J]. MOLECULAR THERAPY-NUCLEIC ACIDS,2018,12(-):433-442. |
| APA | Cai, Lei.,Huang, Tao.,Zhang, Xinxin.,Chen, Wenzhong.,He, Lin.,...&,.(2018).Implications of Newly Identified Brain eQTL Genes and Their Interactors in Schizophrenia.MOLECULAR THERAPY-NUCLEIC ACIDS,12(-),433-442. |
| MLA | Cai, Lei,et al."Implications of Newly Identified Brain eQTL Genes and Their Interactors in Schizophrenia".MOLECULAR THERAPY-NUCLEIC ACIDS 12.-(2018):433-442. |
入库方式： OAI收割
来源：上海营养与健康研究所
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