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Smoking Cessation, Weight Change, Type 2 Diabetes, and Mortality

文献类型：期刊论文

作者Hu, Yang8,9; Zong, Geng9; Liu, Gang9; Willett, Walter C.6,8,9; Hu, Frank B.6,8,9; Sun, Qi6,9; Wang, Molin8; Manson, JoAnn E.6,8; Wang, Molin6,7; Rosner, Bernard7
刊名NEW ENGLAND JOURNAL OF MEDICINE
出版日期2018
卷号379期号:7页码:623-632
关键词miRNA-mRNA interaction network pancreatic cancer RNA-seq transcriptome
ISSN号0028-4793
DOI10.1056/NEJMoa1803626
文献子类Article
英文摘要BACKGROUND Whether weight gain after smoking cessation attenuates the health benefits of quitting is unclear. METHODS In three cohort studies involving men and women in the United States, we identified those who had reported quitting smoking and we prospectively assessed changes in smoking status and body weight. We estimated risks of type 2 diabetes, death from cardiovascular disease, and death from any cause among those who had reported quitting smoking, according to weight changes after smoking cessation. RESULTS The risk of type 2 diabetes was higher among recent quitters (2 to 6 years since smoking cessation) than among current smokers (hazard ratio, 1.22; 95% confidence interval [CI], 1.12 to 1.32). The risk peaked 5 to 7 years after quitting and then gradually decreased. The temporary increase in the risk of type 2 diabetes was directly proportional to weight gain, and the risk was not increased among quitters without weight gain (P<0.001 for interaction). In contrast, quitters did not have a temporary increase in mortality, regardless of weight change after quitting. As compared with current smokers, the hazard ratios for death from cardiovascular disease were 0.69 (95% CI, 0.54 to 0.88) among recent quitters without weight gain, 0.47 (95% CI, 0.35 to 0.63) among those with weight gain of 0.1 to 5.0 kg, 0.25 (95% CI, 0.15 to 0.42) among those with weight gain of 5.1 to 10.0 kg, 0.33 (95% CI, 0.18 to 0.60) among those with weight gain of more than 10.0 kg, and 0.50 (95% CI, 0.46 to 0.55) among longer- term quitters (> 6 years since smoking cessation). Similar associations were observed for death from any cause. CONCLUSIONS Smoking cessation that was accompanied by substantial weight gain was associated with an increased short-term risk of type 2 diabetes but did not mitigate the benefits of quitting smoking on reducing cardiovascular and all-cause mortality. (Funded by the National Institutes of Health.)
学科主题General & Internal Medicine
WOS关键词CORONARY-HEART-DISEASE ; PHYSICAL-ACTIVITY ; WOMEN ; RISK ; GAIN ; MELLITUS ; HEALTH ; ASSOCIATION ; ABSTINENCE ; MEN
语种英语
WOS记录号WOS:000441659100006
出版者MASSACHUSETTS MEDICAL SOC
版本出版稿
源URL[http://202.127.25.144/handle/331004/509]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Harvard Med Sch, Boston, MA USA;
2.Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, State Key Lab Environm Hlth Incubating, Wuhan, Hubei, Peoples R China,
3.Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, Dept Epidemiol & Biostat,Minist Educ,Key Lab Envi, Wuhan, Hubei, Peoples R China;
4.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr Metab & Food Safety,Inst Nutr & Hlth, Shanghai, Peoples R China;
5.Brigham & Womens Hosp, Dept Med, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA;
6.Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA;
7.Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA;
8.Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA;
9.Harvard TH Chan Sch Publ Hlth, Dept Nutr, 665 Huntington Ave, Boston, MA 02115 USA;
推荐引用方式
GB/T 7714		 Hu, Yang,Zong, Geng,Liu, Gang,et al. Smoking Cessation, Weight Change, Type 2 Diabetes, and Mortality[J]. NEW ENGLAND JOURNAL OF MEDICINE,2018,379(7):623-632.
APA Hu, Yang.,Zong, Geng.,Liu, Gang.,Willett, Walter C..,Hu, Frank B..,...&,.(2018).Smoking Cessation, Weight Change, Type 2 Diabetes, and Mortality.NEW ENGLAND JOURNAL OF MEDICINE,379(7),623-632.
MLA Hu, Yang,et al."Smoking Cessation, Weight Change, Type 2 Diabetes, and Mortality".NEW ENGLAND JOURNAL OF MEDICINE 379.7(2018):623-632.

入库方式： OAI收割

来源：上海营养与健康研究所

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