A CD44v(+) subpopulation of breast cancer stem-like cells with enhanced lung metastasis capacity
文献类型：期刊论文
| 作者 | Hu, Jing1,2; Zhang, Peiyuan1,2; Zhuang, Xueqian1,2; Hu, Guohong1,2; Li, Gang1; , |
| 刊名 | CELL DEATH & DISEASE
 |
| 出版日期 | 2017 |
| 卷号 | 8期号:-页码:e2679 |
| 关键词 | alternative splicing U2-related splicing factors cancer cell proliferation apoptosis cancer development double-stranded DNA breaks splicing regulation |
| ISSN号 | 2041-4889 |
| DOI | 10.1038/cddis.2017.72 |
| 文献子类 | Article |
| 英文摘要 | Cancer stem-like cells (CSCs) are a subpopulation of cancer cells responsible for tumor growth, and recent evidence suggests that CSCs also contribute to cancer metastasis. However, the heterogeneity of CSCs in metastasis capacities is still unclear in breast cancer. Here we show that among the CD24(-)/CD44(+) breast CSCs, a subset expressing the variant isoform of CD44 (CD44v) displays significantly higher capacity of lung metastasis than that expressing the standard CD44 isoform CD44s. Increasing or reducing the CD44v/CD44s ratio of breast cancer cells by regulating the expression of epithelial splicing regulatory protein 1 (ESRP1) leads to promotion or suppression of lung metastasis without influencing cancer cell stemness. Directly suppressing CD44v expression significantly alleviates the metastasis burden in lungs. Mechanically, CD44v, but not CD44s, responds to osteopontin (OPN) in the lung environment to enhance cancer cell invasiveness and promote lung metastasis. In clinical samples expression of ESRP1 and CD44v, rather than CD44s or total CD44, positively correlates with distant metastasis. Overall, our data identify a subset of metastatic breast CSCs characterized by CD44v expression, and suggest that CD44v and ESRP1 might be better prognosis markers and therapeutic targets for breast cancer metastasis. |
| 学科主题 | Cell Biology |
| WOS关键词 | HUMAN COLORECTAL-CANCER ; TUMOR-INITIATING CELLS ; HUMAN OVARIAN-CANCER ; PHENOTYPIC CHARACTERIZATION ; PROSPECTIVE IDENTIFICATION ; PANCREATIC-CANCER ; VARIANT ISOFORMS ; CARCINOMA CELLS ; POOR-PROGNOSIS ; SOLID TUMORS |
| 语种 | 英语 |
| WOS记录号 | WOS:000397447100019 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/512]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Univ Chinese Acad Sci, Sch Med, 320 Yueyang Rd, Shanghai, Peoples R China, 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol, 320 Yueyang Rd, Beijing 100864, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Hu, Jing,Zhang, Peiyuan,Zhuang, Xueqian,et al. A CD44v(+) subpopulation of breast cancer stem-like cells with enhanced lung metastasis capacity[J]. CELL DEATH & DISEASE,2017,8(-):e2679. |
| APA | Hu, Jing,Zhang, Peiyuan,Zhuang, Xueqian,Hu, Guohong,Li, Gang,&,.(2017).A CD44v(+) subpopulation of breast cancer stem-like cells with enhanced lung metastasis capacity.CELL DEATH & DISEASE,8(-),e2679. |
| MLA | Hu, Jing,et al."A CD44v(+) subpopulation of breast cancer stem-like cells with enhanced lung metastasis capacity".CELL DEATH & DISEASE 8.-(2017):e2679. |
入库方式： OAI收割
来源：上海营养与健康研究所
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