ATF4/ATG5 Signaling in Hypothalamic Proopiomelanocortin Neurons Regulates Fat Mass via Affecting Energy Expenditure
文献类型：期刊论文
| 作者 | Xiao, Yuzhong; Deng, Yalan; Yuan, Feixiang; Xia, Tingting; Liu, Hao; Li, Zhigang; Liu, Zhixue; Ying, Hao; Liu, Yi; Zhai, Qiwei |
| 刊名 | DIABETES
 |
| 出版日期 | 2017 |
| 卷号 | 66期号:5页码:1146-1158 |
| 关键词 | lncRNA rice heading date yield |
| ISSN号 | 0012-1797 |
| DOI | 10.2337/db16-1546 |
| 文献子类 | Article |
| 英文摘要 | Although many biological functions of activating transcription factor 4 (ATF4) have been identified, a role of hypothalamic ATF4 in the regulation of energy homeostasis is poorly understood. In this study, we showed that hypothalamic proopiomelanocortin (POMC) neuron-specific ATF4 knockout (PAKO) mice are lean and have higher energy expenditure. Furthermore, PAKO mice were resistant to high-fat diet-induced obesity, glucose intolerance, and leptin resistance. Moreover, the expression of autophagy protein 5 (ATG5) was increased or decreased by ATF4 knockdown or overexpression, respectively, and ATF4 inhibited the transcription of ATG5 by binding to the basic zipper-containing protein sites on its promoter. Importantly, mice with double knockout of ATF4 and ATG5 in POMC neurons gained more fat mass and reduced energy expenditure compared with PAKO mice under a high-fat diet. Finally, the effect of ATF4 deletion in POMC neurons was possibly mediated via enhanced ATG5-dependent autophagy and -melanocyte-stimulating hormone production in the hypothalamus. Taken together, these results identify the beneficial role of hypothalamic ATF4/ATG5 axis in the regulation of energy expenditure, obesity, and obesity-related metabolic disorders, which suggests that ATF4/ATG5 axis in the hypothalamus may be a new potential therapeutic target for treating obesity and obesity-related metabolic diseases. |
| 学科主题 | Endocrinology & Metabolism |
| WOS关键词 | DIET-INDUCED OBESITY ; CONNECTS ER STRESS ; LIPID-METABOLISM ; LIVER STEATOSIS ; LEPTIN ACTION ; AGRP NEURONS ; AMINO-ACID ; AUTOPHAGY ; MICE ; BALANCE |
| 语种 | 英语 |
| WOS记录号 | WOS:000399799800011 |
| 出版者 | AMER DIABETES ASSOC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/515]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | Univ Chinese Acad Sci, Key Lab Nutr & Metab, Inst Nutr Sci, Shanghai Inst Biol Sci,Chinese Acad Sci, Shanghai, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Xiao, Yuzhong,Deng, Yalan,Yuan, Feixiang,et al. ATF4/ATG5 Signaling in Hypothalamic Proopiomelanocortin Neurons Regulates Fat Mass via Affecting Energy Expenditure[J]. DIABETES,2017,66(5):1146-1158. |
| APA | Xiao, Yuzhong.,Deng, Yalan.,Yuan, Feixiang.,Xia, Tingting.,Liu, Hao.,...&,.(2017).ATF4/ATG5 Signaling in Hypothalamic Proopiomelanocortin Neurons Regulates Fat Mass via Affecting Energy Expenditure.DIABETES,66(5),1146-1158. |
| MLA | Xiao, Yuzhong,et al."ATF4/ATG5 Signaling in Hypothalamic Proopiomelanocortin Neurons Regulates Fat Mass via Affecting Energy Expenditure".DIABETES 66.5(2017):1146-1158. |
入库方式： OAI收割
来源：上海营养与健康研究所
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