microRNA-378 promotes autophagy and inhibits apoptosis in skeletal muscle
文献类型：期刊论文
| 作者 | Li, Yan1,2; Zhang, Hui2; Qian, Haifeng2; Wang, Li2; Liu, Wei1; Wang, Hui1; Liu, Shengnan1; Li, Peng1; Zhang, Shengjie1; Sun, Chao1 |
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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| 出版日期 | 2018 |
| 卷号 | 115期号:46页码:E10849-E10858 |
| 关键词 | miR-378 skeletal muscle autophagy apoptosis |
| ISSN号 | 0027-8424 |
| DOI | 10.1073/pnas.1803377115 |
| 文献子类 | Article |
| 英文摘要 | The metabolic regulation of cell death is sophisticated. A growing body of evidence suggests the existence of multiple metabolic checkpoints that dictate cell fate in response to metabolic fluctuations. However, whether microRNAs (miRNAs) are able to respond to metabolic stress, reset the threshold of cell death, and attempt to reestablish homeostasis is largely unknown. Here, we show that miR-378/378* KO mice cannot maintain normal muscle weight and have poor running performance, which is accompanied by impaired autophagy, accumulation of abnormal mitochondria, and excessive apoptosis in skeletal muscle, whereas miR-378 overexpression is able to enhance autophagy and repress apoptosis in skeletal muscle of mice. Our in vitro data show that metabolic stress-responsive miR-378 promotes autophagy and inhibits apoptosis in a cell-autonomous manner. Mechanistically, miR-378 promotes autophagy initiation through the mammalian target of rapamycin (mTOR)/unc-51-like autophagy activating kinase 1 (ULK1) pathway and sustains autophagy via Forkhead box class 0 (FoxO)-mediated transcriptional reinforcement by targeting phosphoinositide-dependent protein kinase 1 (PDK1). Meanwhile, miR-378 suppresses intrinsic apoptosis initiation directly through targeting an initiator caspase- Caspase 9. Thus, we propose that miR-378 is a critical component of metabolic checkpoints, which integrates metabolic information into an adaptive response to reduce the propensity of myocytes to undergo apoptosis by enhancing the autophagic process and blocking apoptotic initiation. Lastly, our data suggest that inflammation-induced down-regulation of miR-378 might contribute to the pathogenesis of muscle dystrophy. |
| 学科主题 | Science & Technology - Other Topics |
| WOS关键词 | BREAST-CANCER CELLS ; UBIQUITIN LIGASES ; ATROPHY ; HOMEOSTASIS ; PATHWAY ; DEATH ; OVEREXPRESSION ; DEGRADATION ; ACTIVATION ; DYSTROPHY |
| 语种 | 英语 |
| WOS记录号 | WOS:000449934400007 |
| 出版者 | NATL ACAD SCIENCES |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/516]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Nutr Metab & Food Safety, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China; 2.Jiangnan Univ, Sch Food Sci & Technol, State Key Lab Food Sci & Technol, Wuxi 214122, Peoples R China; 3.Fudan Univ, Zhongshan Hosp, Dept Endocrinol & Metab, Shanghai 200032, Peoples R China; 4.Minist Hlth, Key Lab Food Safety Risk Assessment, Beijing 100021, Peoples R China, 5.Boston Univ, Div Pulm & Crit Care Med, Dept Med, Med Campus, Boston, MA 02118 USA; 6.Fudan Univ, Childrens Hosp, Dept Neuromuscular Dis, Shanghai 201102, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li, Yan,Zhang, Hui,Qian, Haifeng,et al. microRNA-378 promotes autophagy and inhibits apoptosis in skeletal muscle[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2018,115(46):E10849-E10858. |
| APA | Li, Yan.,Zhang, Hui.,Qian, Haifeng.,Wang, Li.,Liu, Wei.,...&,.(2018).microRNA-378 promotes autophagy and inhibits apoptosis in skeletal muscle.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,115(46),E10849-E10858. |
| MLA | Li, Yan,et al."microRNA-378 promotes autophagy and inhibits apoptosis in skeletal muscle".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 115.46(2018):E10849-E10858. |
入库方式： OAI收割
来源：上海营养与健康研究所
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