Angiopoietin-2 in white adipose tissue improves metabolic homeostasis through enhanced angiogenesis
文献类型：期刊论文
| 作者 | An, Yu A.1; Sun, Kai1; Joffin, Nolwenn1; Zhang, Fang1; Deng, Yingfeng1; Kusminski, Christine M.1; Scherer, Philipp E.1; Sun, Kai4; Zhang, Fang3; Donze, Olivier5 |
| 刊名 | ELIFE
 |
| 出版日期 | 2017 |
| 卷号 | 6期号:-页码:e24071 |
| ISSN号 | 2050-084X |
| 关键词 | Indo-European populations Y-chromosomal haplogroup mitochondrial DNA haplogroup lexical system phonemic system |
| DOI | 10.7554/eLife.24071 |
| 文献子类 | Article |
| 英文摘要 | Despite many angiogenic factors playing crucial roles in metabolic homeostasis, effects of angiopoietin-2 (ANG-2) in adipose tissue (AT) remain unclear. Utilizing a doxycycline-inducible AT-specific ANG-2 overexpression mouse model, we assessed the effects of ANG-2 in AT expansion upon a high-fat diet (HFD) challenge. ANG-2 is significantly induced, with subcutaneous white AT (sWAT) displaying the highest ANG-2 expression. ANG-2 overexpressing mice show increased sWAT vascularization and are resistant to HFD-induced obesity. In addition, improved glucose and lipid metabolism are observed. Mechanistically, the sWAT displays a healthier expansion pattern with increased anti-inflammatory macrophage infiltration. Conversely, ANG-2 neutralization in HFD-challenged wild-type mice shows reduced vascularization in sWAT, associated with impaired glucose tolerance and lipid clearance. Blocking ANG-2 causes significant proinflammatory and pro-fibrotic changes, hallmarks of an unhealthy AT expansion. In contrast to other pro-angiogenic factors, such as vascular endothelial growth factor-A (VEGF-A), this is achieved without any enhanced beiging of white AT. |
| 学科主题 | Life Sciences & Biomedicine - Other Topics |
| WOS关键词 | DIET-INDUCED OBESITY ; VEGF-A ; STIMULATES ANGIOGENESIS ; INSULIN SENSITIVITY ; MICE ; INFLAMMATION ; VASCULATURE ; DYSFUNCTION ; MODULATION ; EXPRESSION |
| 语种 | 英语 |
| 出版者 | ELIFE SCIENCES PUBLICATIONS LTD |
| WOS记录号 | WOS:000399017000001 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/517]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Touchstone Diabet Ctr, Dallas, TX 75390 USA; 2.Univ Texas Southwestern Med Ctr Dallas, Dept Cell Biol, Dallas, TX 75390 USA, 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai, Peoples R China; 4.Univ Texas Hlth Sci Ctr Houston, Brown Fdn Inst Mol Med, Ctr Metab & Degenerat Dis, Houston, TX 77030 USA; 5.AdipoGen Life Sci, Epalinges, Switzerland; |
| 推荐引用方式 GB/T 7714 | An, Yu A.,Sun, Kai,Joffin, Nolwenn,et al. Angiopoietin-2 in white adipose tissue improves metabolic homeostasis through enhanced angiogenesis[J]. ELIFE,2017,6(-):e24071. |
| APA | An, Yu A..,Sun, Kai.,Joffin, Nolwenn.,Zhang, Fang.,Deng, Yingfeng.,...&,.(2017).Angiopoietin-2 in white adipose tissue improves metabolic homeostasis through enhanced angiogenesis.ELIFE,6(-),e24071. |
| MLA | An, Yu A.,et al."Angiopoietin-2 in white adipose tissue improves metabolic homeostasis through enhanced angiogenesis".ELIFE 6.-(2017):e24071. |
入库方式： OAI收割
来源：上海营养与健康研究所
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