Association of maternal and fetal LEPR common variants with maternal glycemic traits during pregnancy
文献类型：期刊论文
| 作者 | Lin, Rong1; Zeng, Liangliang1; Sun, Yuantian1; Su, Zhenyu1; Ju, Hongfang2; Yuan, Ziyu3,4,5; Yang, Yajun3,4,5; Jin, Li3,4,5; Wang, Yi4,5; Jin, Li6 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:-页码:3112 |
| 关键词 | growth differentiation factor 15 hyperthyroidism thyroid hormone cytokine brown adipose tissue |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-017-03518-x |
| 文献子类 | Article |
| 英文摘要 | Recent studies suggested that maternal and placental leptin receptor (LEPR) may be involved in maternal glucose metabolism in pregnancy. To identify maternal and fetal LEPR common variants influencing gestational glycemic traits, we performed association study of 24-28-week maternal fasting glucose, glucose 1 hour after the consumption of a 50-g oral glucose load, fasting insulin and indices of beta-cell function (HOMA-beta) and insulin resistance (HOMA-IR) in 1,112 unrelated women and their children. Follow-up of 36 LEPR loci identified 3 maternal loci (rs10889567, rs1137101 and rs3762274) associated with fasting glucose, these 3 fetal loci associated with fasting insulin and HOMA1-IR, as well as these 3 maternal-fetal loci combinations associated with HOMA2-beta. We also demonstrated association of maternal locus rs7554485 with HOMA2-beta and HOMA2-IR, maternal locus rs10749754 with fasting glucose, fetal locus rs10749754 with HOMA2-IR. However, these associations were no longer statistically significant after Bonferroni correction. In conclusion, our results first revealed multiple associations between maternal and fetal LEPR common variants and gestational glycemic traits. These associations did not survive Bonferroni correction. These corrections are overly conservative for association studies. We therefore believe the influence of these nominally significant variants on gestational glycometabolism will be confirmed by additional studies. |
| 学科主题 | Science & Technology - Other Topics |
| WOS关键词 | GESTATIONAL DIABETES-MELLITUS ; GENOME-WIDE ASSOCIATION ; SOLUBLE LEPTIN RECEPTOR ; INSULIN-RESISTANCE ; GENE POLYMORPHISMS ; GLN223ARG POLYMORPHISMS ; CARDIOVASCULAR-DISEASE ; INTRAVENOUS GLUCOSE ; CHINESE POPULATION ; WOMEN |
| 语种 | 英语 |
| WOS记录号 | WOS:000402865200024 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/521]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Hainan Med Coll, Dept Biol, Haikou, Hainan, Peoples R China; 2.Taizhou Peoples Hosp, Dept Gynaecol & Obstet, Taizhou, Jiangsu, Peoples R China; 3.Fudan Taizhou Inst Hlth Sci, Taizhou, Jiangsu, Peoples R China; 4.Fudan Univ, Minist Educ, Key Lab Contemporary Anthropol, Collaborat Innovat Ctr Genet & Dev,Sch Life Sci, Shanghai, Peoples R China; 5.Fudan Univ, Collaborat Innovat Ctr Genet & Dev, Sch Life Sci, State Key Lab Genet Engn, Shanghai, Peoples R China; 6.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Shanghai, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Lin, Rong,Zeng, Liangliang,Sun, Yuantian,et al. Association of maternal and fetal LEPR common variants with maternal glycemic traits during pregnancy[J]. SCIENTIFIC REPORTS,2017,7(-):3112. |
| APA | Lin, Rong.,Zeng, Liangliang.,Sun, Yuantian.,Su, Zhenyu.,Ju, Hongfang.,...&,.(2017).Association of maternal and fetal LEPR common variants with maternal glycemic traits during pregnancy.SCIENTIFIC REPORTS,7(-),3112. |
| MLA | Lin, Rong,et al."Association of maternal and fetal LEPR common variants with maternal glycemic traits during pregnancy".SCIENTIFIC REPORTS 7.-(2017):3112. |
入库方式： OAI收割
来源：上海营养与健康研究所
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