BCCIP beta modulates the ribosomal and extraribosomal function of S7 through a direct interaction
文献类型：期刊论文
| 作者 | Ba, Qian2; Li, Xiaoguang2; Chen, Peizhan2; Li, Jingquan2; Wang, Hui2,3; Huang, Chao3; Li, Junyang3; Fu, Yijing3; Duan, Juan3; Hao, Miao3 |
| 刊名 | JOURNAL OF MOLECULAR CELL BIOLOGY
 |
| 出版日期 | 2017 |
| 卷号 | 9期号:3页码:209-219 |
| 关键词 | BCCIP beta ribosomal protein S7 translation ribosomal stress tumor suppressor |
| ISSN号 | 1674-2788 |
| DOI | 10.1093/jmcb/mjx019 |
| 文献子类 | Article |
| 英文摘要 | Extraribosomal functions of ribosomal proteins (RPs) have gained much attention for their implications in tumorigenesis and progression. However, the regulations for transition between the ribosomal and extraribosomal functions of RPs are rarely reported. Herein, we identified a ribosomal protein S7-interacting partner, BCCIP beta, which modulates the functional conversion of S7. Through the N-terminal acidic domain, BCCIP beta interacts with the central basic region in S7 and regulates the extraribosomal distribution of S7. BCCIP beta deficiency abrogates the ribosomal accumulation but enhances the ribosome-free location of S7. This translocation further impairs protein synthesis and triggers ribosomal stress. Consequently, BCCIP beta deficiency suppresses the ribosomal function and initiates the extraribosomal function of S7, resulting in restriction of cell proliferation. Moreover, clinically relevant S7 mutations were found to dampen the interaction with BCCIP beta and facilitate the functional transition of S7. In conclusion, BCCIP beta, as a S7 modulator, contributes to the regulation of ribosomal and extraribosomal functions of S7 and has implications in cell growth and tumor development. |
| 学科主题 | Cell Biology |
| WOS关键词 | PROTEIN L26 ; DNA-DAMAGE ; P53 ; INHIBITION ; MDM2 ; TRANSLATION ; CANCER ; PROGRESSION ; ACTIVATION ; STRESS |
| 语种 | 英语 |
| WOS记录号 | WOS:000403827500004 |
| 出版者 | OXFORD UNIV PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/525]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Rutgers State Univ, Robert Wood Johnson Med Sch, Dept Radiat Oncol, Rutgers Canc Inst New Jersey, New Brunswick, NJ 08903 USA, 2.Shanghai Jiao Tong Univ, Sch Publ Hlth, Sch Med, Shanghai 200025, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab food safety Res, Shanghai 200031, Peoples R China; 4.Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China; 5.Texas Tech Univ, Hlth Sci Ctr, Dept Pharmaceut Sci, Sch Pharm, Amarillo, TX 79106 USA; |
| 推荐引用方式 GB/T 7714 | Ba, Qian,Li, Xiaoguang,Chen, Peizhan,et al. BCCIP beta modulates the ribosomal and extraribosomal function of S7 through a direct interaction[J]. JOURNAL OF MOLECULAR CELL BIOLOGY,2017,9(3):209-219. |
| APA | Ba, Qian.,Li, Xiaoguang.,Chen, Peizhan.,Li, Jingquan.,Wang, Hui.,...&,.(2017).BCCIP beta modulates the ribosomal and extraribosomal function of S7 through a direct interaction.JOURNAL OF MOLECULAR CELL BIOLOGY,9(3),209-219. |
| MLA | Ba, Qian,et al."BCCIP beta modulates the ribosomal and extraribosomal function of S7 through a direct interaction".JOURNAL OF MOLECULAR CELL BIOLOGY 9.3(2017):209-219. |
入库方式： OAI收割
来源：上海营养与健康研究所
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