中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海营养与健康研究所
  3. 中国科学院上海生命科学研究院营养科学研究所
Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels

文献类型：期刊论文

作者Spracklen, Cassandra N.71; Wu, Ying71; Cannon, Maren E.71; Roman, Tamara S.71; Mohlke, Karen L.71; Chen, Peng2,72; Koh, Woon-Puay28,72; Liu, Jianjun18,72; Teo, Yik-Ying4,18,72; van Dam, Rob M.72
刊名HUMAN MOLECULAR GENETICS
出版日期2017
卷号26期号:9页码:1770-1784
ISSN号0964-6906
DOI10.1093/hmg/ddx062
文献子类Article
英文摘要Large-scale meta-analyses of genome-wide association studies (GWAS) have identified > 175 loci associated with fasting cholesterol levels, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). With differences in linkage disequilibrium (LD) structure and allele frequencies between ancestry groups, studies in additional large samples may detect new associations. We conducted staged GWAS meta-analyses in up to 69,414 East Asian individuals from 24 studies with participants from Japan, the Philippines, Korea, China, Singapore, and Taiwan. These meta-analyses identified (P < 5 x 10(-8)) three novel loci associated with HDL-C near CD163-APOBEC1 (P = 7.4 x 10(-9)), NCOA2 (P = 1.6 x 10(-8)), and NID2-PTGDR (P = 4.2 x 10(-8)), and one novel locus associated with TG near WDR11-FGFR2 (P = 2.7 x 10(-10)). Conditional analyses identified a second signal near CD163-APOBEC1. We then combined results from the East Asian meta-analysis with association results from up to 187,365 European individuals from the Global Lipids Genetics Consortium in a trans-ancestry meta-analysis. This analysis identified (log(10)Bayes Factor a 6.1) eight additional novel lipid loci. Among the twelve total loci identified, the index variants at eight loci have demonstrated at least nominal significance with other metabolic traits in prior studies, and two loci exhibited coincident eQTLs (P < 1 x 10(-5)) in subcutaneous adipose tissue for BPTF and PDGFC. Taken together, these analyses identified multiple novel lipid loci, providing new potential therapeutic targets.
学科主题Biochemistry & Molecular Biology ; Genetics & Heredity
WOS关键词GENOME-WIDE ASSOCIATION ; CODING-SEQUENCE VARIANTS ; PROTEIN-COUPLED RECEPTOR ; GENETIC ARCHITECTURE ; ETHNIC METAANALYSIS ; GENOTYPE IMPUTATION ; FASTING GLUCOSE ; COMMON VARIANTS ; LOW-FREQUENCY ; BLOOD-LIPIDS
语种英语
WOS记录号WOS:000400912200015
出版者OXFORD UNIV PRESS
版本出版稿
源URL[http://202.127.25.144/handle/331004/526]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Tunghai Univ, Dept Social Work, Taichung, Taiwan;
2.Jilin Univ, Key Lab Pathobiol, Minist Educ, Changchun, Peoples R China;
3.Korean Natl Inst Hlth, Div Struct & Funct Genom, Ctr Genome Sci, Osong, Chungchungbuk D, South Korea;
4.Natl Univ Singapore, Inst Life Sci, Singapore, Singapore;
5.Taichung Vet Gen Hosp, Dept Ophthalmol, Taichung, Taiwan;
6.Vanderbilt Univ, Med Ctr, Dept Med, Div Epidemiol,Vanderbilt Ingram Canc Ctr, Nashville, TN USA;
7.Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA;
8.Capital Med Univ, Beijing Inst Ophthalmol, Beijing Ophthalmol & Visual Sci Key Lab, Beijing Tongren Eye,Ctr Beijing Tongren Hosp, Beijing, Peoples R China;
9.Natl Ctr Global Hlth & Med, Tokyo, Japan;
10.Acad Sinica, Inst Biomed Sci, Taipei, Taiwan;
推荐引用方式
GB/T 7714		 Spracklen, Cassandra N.,Wu, Ying,Cannon, Maren E.,et al. Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels[J]. HUMAN MOLECULAR GENETICS,2017,26(9):1770-1784.
APA Spracklen, Cassandra N..,Wu, Ying.,Cannon, Maren E..,Roman, Tamara S..,Mohlke, Karen L..,...&,.(2017).Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.HUMAN MOLECULAR GENETICS,26(9),1770-1784.
MLA Spracklen, Cassandra N.,et al."Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels".HUMAN MOLECULAR GENETICS 26.9(2017):1770-1784.

入库方式： OAI收割

来源：上海营养与健康研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。