Host-Microbiome Synergistic Control on Sphingolipid Metabolism by Mechanotransduction in Model Arthritis
文献类型：期刊论文
| 作者 | Zhou, Xiaoyuan1,2,3; Devescovi, Valentina2,3; Liu, Yuanhua2,3; Nardini, Christine2,3; Liu, Yuanhua4; Dent, Jennifer E.5; Nardini, Christine6,7,8; , |
| 刊名 | BIOMOLECULES
 |
| 出版日期 | 2019 |
| 卷号 | 9期号:4页码:144 |
| 关键词 | rheumatoid arthritis host-microbiome interaction sphingolipids metabolism Prevotella sp iNKT |
| ISSN号 | 2218-273X |
| DOI | 10.3390/biom9040144 |
| 文献子类 | Article |
| 英文摘要 | Chronic inflammatory autoimmune disorders are systemic diseases with increasing incidence and still lack a cure. More recently, attention has been placed in understanding gastrointestinal (GI) dysbiosis and, although important progress has been made in this area, it is currently unclear to what extent microbiome manipulation can be used in the treatment of autoimmune disorders. Via the use of appropriate models, rheumatoid arthritis (RA), a well-known exemplar of such pathologies, can be exploited to shed light on the currently overlooked effects of existing therapies on the GI microbiome. In this direction, we here explore the crosstalk between the GI microbiome and the host immunity in model arthritis (collagen induced arthritis, CIA). By exploiting omics from samples of limited invasiveness (blood and stools), we assess the host-microbiome responses to standard therapy (methotrexate, MTX) combined with mechanical subcutaneous stimulation (MS) and to mechanical stimulation alone. When MS is involved, results reveal the sphingolipid metabolism as the trait d'union among known hallmarks of (model) RA, namely: Imbalance in the S1P-S1PR1 axis, expansion of Prevotella sp., and invariant Natural Killer T (iNKT)-penia, thus offering the base of a rationale to mechanically modulate this pathway as a therapeutic target in RA. |
| 学科主题 | Biochemistry & Molecular Biology |
| WOS关键词 | RNA GENE DATABASE ; LACTOBACILLUS ; SPHINGOSINE-1-PHOSPHATE ; GLYCOSAMINOGLYCANS ; TRANSPLANTATION ; COLLAGEN ; MUSCLE ; VIRUS |
| 语种 | 英语 |
| WOS记录号 | WOS:000467318400027 |
| 出版者 | MDPI |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/527]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA; 2.Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Shanghai 200031, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 4.Chinese Acad Sci, Inst Pasteur Shanghai, Bioinformat Platform, Shanghai 200031, Peoples R China; 5.NORSAS Consultancy Ltd, Norwich NR128QP, Norfolk, England; 6.Karolinska Inst, Dept Lab Med, Div Clin Chem, S-17177 Stockholm, Sweden; 7.SOL Grp Srl, Sci & Med Direct, I-20900 Monza, Italy; 8.CNR, IAC Mauro Picone, I-00185 Rome, Italy, |
| 推荐引用方式 GB/T 7714 | Zhou, Xiaoyuan,Devescovi, Valentina,Liu, Yuanhua,et al. Host-Microbiome Synergistic Control on Sphingolipid Metabolism by Mechanotransduction in Model Arthritis[J]. BIOMOLECULES,2019,9(4):144. |
| APA | Zhou, Xiaoyuan.,Devescovi, Valentina.,Liu, Yuanhua.,Nardini, Christine.,Liu, Yuanhua.,...&,.(2019).Host-Microbiome Synergistic Control on Sphingolipid Metabolism by Mechanotransduction in Model Arthritis.BIOMOLECULES,9(4),144. |
| MLA | Zhou, Xiaoyuan,et al."Host-Microbiome Synergistic Control on Sphingolipid Metabolism by Mechanotransduction in Model Arthritis".BIOMOLECULES 9.4(2019):144. |
入库方式： OAI收割
来源：上海营养与健康研究所
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