A Pharmacogenomic Landscape in Human Liver Cancers
文献类型：期刊论文
| 作者 | Qiu, Zhixin13; Zhang, Zhengtao13; Li, Chun13; Wang, Chenhua13; Cen, Jin13; Chen, Xiaotao13; Shu, Yajing13; Zhang, Zhao13; Sun, Lulu13; Min, Lihua13 |
| 刊名 | CANCER CELL
 |
| 出版日期 | 2019 |
| 卷号 | 36期号:2页码:179-+ |
| ISSN号 | 1535-6108 |
| 关键词 | association GSK-3 beta BDNF major depressive disorder venlafaxine |
| DOI | 10.1016/j.ccell.2019.07.001 |
| 文献子类 | Article |
| 英文摘要 | Liver cancers are highly heterogeneous with poor prognosis and drug response. A better understanding between genetic alterations and drug responses would facilitate precision treatment for liver cancers. To characterize the landscape of pharmacogenomic interactions in liver cancers, we developed a protocol to establish human liver cancer cell models at a success rate of around 50% and generated the Liver Cancer Model Repository (LIMORE) with 81 cell models. LIMORE represented genomic and transcriptomic heterogeneity of primary cancers. Interrogation of the pharmacogenomic landscape of LIMORE discovered unexplored gene-drug associations, including synthetic lethalities to prevalent alterations in liver cancers. Moreover, predictive biomarker candidates were suggested for the selection of sorafenib-responding patients. LIMORE provides a rich resource facilitating drug discovery in liver cancers. |
| 学科主题 | Oncology ; Cell Biology |
| WOS关键词 | HEPATITIS-B-VIRUS ; HEPATOCELLULAR-CARCINOMA ; ORGANOID CULTURES ; CELL-LINES ; MUTATIONAL LANDSCAPE ; LARGE-SCALE ; MODELS ; GENOME ; CATENIN ; SENSITIVITY |
| 语种 | 英语 |
| 出版者 | CELL PRESS |
| WOS记录号 | WOS:000480434200008 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/528]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Fudan Univ, Liver Canc Inst, Zhongshan Hosp, Key Lab Carcinogenesis & Canc Invas, Shanghai 200032, Peoples R China; 2.Chinese Acad Sci, Biores Innovat Ctr Suzhou, Shanghai Inst Biochem & Cell Biol, Suzhou 215121, Jiangsu, Peoples R China, 3.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; 4.Fudan Univ, Zhongshan Hosp, Dept Pathol, Shanghai 200032, Peoples R China; 5.Nanjing Univ, Med Sch, Affiliated Drum Tower Hosp, Dept Hepatobiliary Surg, Nanjing 211166, Jiangsu, Peoples R China; 6.Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10065 USA; 7.Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Hepat Surg 5, Shanghai 200438, Peoples R China; 8.Shanghai ChemPartner Co Ltd, Shanghai 201203, Peoples R China; 9.Nanjing Med Univ, Liver Transplantat Ctr, Key Lab Living Donor Liver Transplantat, Minist Publ Hlth,Affiliated Hosp 1, Nanjing 210029, Jiangsu, Peoples R China; 10.Shanghai Jiao Tong Univ, SJTU Yale Joint Ctr Biostat, Dept Bioinformat & Biostat, Shanghai 200240, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Qiu, Zhixin,Zhang, Zhengtao,Li, Chun,et al. A Pharmacogenomic Landscape in Human Liver Cancers[J]. CANCER CELL,2019,36(2):179-+. |
| APA | Qiu, Zhixin.,Zhang, Zhengtao.,Li, Chun.,Wang, Chenhua.,Cen, Jin.,...&,.(2019).A Pharmacogenomic Landscape in Human Liver Cancers.CANCER CELL,36(2),179-+. |
| MLA | Qiu, Zhixin,et al."A Pharmacogenomic Landscape in Human Liver Cancers".CANCER CELL 36.2(2019):179-+. |
入库方式： OAI收割
来源：上海营养与健康研究所
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