An Adipose Tissue Atlas: An Image-Guided Identification of Human-like BAT and Beige Depots in Rodents
文献类型：期刊论文
| 作者 | Zhang, Fang2,3; Shao, Mengle2; An, Yu2; Wang, Qiong2; Zhu, Yi2; Kusminski, Christine M.2; Gupta, Rana K.2; Scherer, Philipp E.2; Zhai, Qiwei3; Hao, Guiyang1 |
| 刊名 | CELL METABOLISM
 |
| 出版日期 | 2018 |
| 卷号 | 27期号:1页码:252-+ |
| 关键词 | GdX/UBL4A NF-kappa B p65/RelA inflammation dendritic cells macrophages |
| ISSN号 | 1550-4131 |
| DOI | 10.1016/j.cmet.2017.12.004 |
| 文献子类 | Article |
| 英文摘要 | [F-18]Fluorodeoxyglucose-PET/CT ((18) F-FDG-PET/CT) imaging has been invaluable for visualizing metabolically active adipose tissues in humans with potential anti-diabetic and anti-obesity effects. To explore whether mice display human-like fat depots in anatomically comparable regions, we mapped fat depots using glucose or fatty acid imaging tracers, such as F-18-FDG through PET/CT or [I-123/125]b- methyl-p-iodophenyl-pentadecanoic acid with SPECT/CT imaging, to analogous depots in mice. Using this type of image analysis with both probes, we define a large number of additional areas of high metabolic activity corresponding to novel fat pads. Histological and gene expression analyses validate these regions as bona fide fat pads. Our findings indicate that fat depots of rodents show a high degree of topological similarity to those of humans. Studies involving both glucose and lipid tracers indicate differential preferences for these substrates in different depots and also suggest that fatty acid-based visualized approaches may reveal additional brown adipose tissue and beige depots in humans. |
| 学科主题 | Cell Biology ; Endocrinology & Metabolism |
| WOS关键词 | COLD-EXPOSURE ; ADULT HUMANS ; BROWN FAT ; GLUCOSE-HOMEOSTASIS ; ACID FTHA ; METABOLISM ; ACTIVATION ; THERMOGENESIS ; ADIPOCYTES ; MOUSE |
| 语种 | 英语 |
| WOS记录号 | WOS:000419592800022 |
| 出版者 | CELL PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/529]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Texas Southwestern Med Ctr Dallas, Dept Radiol, Dallas, TX 75390 USA, 2.Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Touchstone Diabet Ctr, Dallas, TX 75390 USA; 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Fang,Shao, Mengle,An, Yu,et al. An Adipose Tissue Atlas: An Image-Guided Identification of Human-like BAT and Beige Depots in Rodents[J]. CELL METABOLISM,2018,27(1):252-+. |
| APA | Zhang, Fang.,Shao, Mengle.,An, Yu.,Wang, Qiong.,Zhu, Yi.,...&,.(2018).An Adipose Tissue Atlas: An Image-Guided Identification of Human-like BAT and Beige Depots in Rodents.CELL METABOLISM,27(1),252-+. |
| MLA | Zhang, Fang,et al."An Adipose Tissue Atlas: An Image-Guided Identification of Human-like BAT and Beige Depots in Rodents".CELL METABOLISM 27.1(2018):252-+. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。