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Alterations of polyunsaturated fatty acid metabolism in ovarian tissues of polycystic ovary syndrome rats

文献类型：期刊论文

作者Huang, Rong1; Li, Shengxian1; Wang, Yuying1; Liu, Wei1,3; Tao, Tao1; Xue, Xinli2; Yin, Huiyong2; Sun, Yun3; Yin, Huiyong4,5,6,7; ,
刊名JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
出版日期2018
卷号22期号:7页码:3388-3396
关键词polycystic ovary syndrome polyunsaturated fatty acids cyclooxygenase cytosolic phospholipase A2 ovarian function
ISSN号1582-4934
DOI10.1111/jcmm.13614
文献子类Article
英文摘要The metabolism of polyunsaturated fatty acids (PUFAs) remains poorly characterized in ovarian tissues of patients with polycystic ovary syndrome (PCOS). This study aimed to explore alterations in the levels of PUFAs and their metabolites in serum and ovarian tissues in a PCOS rat model treated with a high-fat diet and andronate. Levels of PUFAs and their metabolites were measured using gas/liquid chromatography-mass spectrometry after the establishment of a PCOS rat model. Only 3 kinds of PUFAs [linoleic acid, arachidonic acid (AA) and docosahexaenoic acid] were detected in both the circulation and ovarian tissues of the rats, and their concentrations were lower in ovarian tissues than in serum. Moreover, significant differences in the ovarian levels of AA were observed between control, high-fat diet-fed and PCOS rats. The levels of prostaglandins, AA metabolites via the cyclooxygenase (COX) pathway, in ovarian tissues of the PCOS group were significantly increased compared to those in the controls. Further studies on the mechanism underlying this phenomenon showed a correlation between decreased expression of phosphorylated cytosolic phospholipase A2 (p-cPLA2) and increased mRNA and protein expression of COX2, potentially leading to a deeper understanding of altered AA and prostaglandin levels in ovarian tissues of PCOS rats.
学科主题Cell Biology ; Research & Experimental Medicine
WOS关键词PERIOVULATORY FOLLICLES ; PHOSPHOLIPASE A(2) ; GONADOTROPIN ; EXPRESSION ; OVULATION ; PROSTAGLANDINS ; INFLAMMATION ; FERTILITY ; INDUCTION ; WOMEN
语种英语
WOS记录号WOS:000435792300012
出版者WILEY
版本出版稿
源URL[http://202.127.25.144/handle/331004/534]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Shanghai Jiao Tong Univ, Dept Endocrinol & Metab, RenJi Hosp, Sch Med, Shanghai, Peoples R China;
2.Chinese Acad Sci, Key Lab Food Safety Res, Inst Nutr Sci, Shanghai Inst Biol Sci, Shanghai, Peoples R China;
3.Shanghai Jiao Tong Univ, Shanghai Key Lab Assisted Reprod & Reprod Genet, Ctr Reprod Med, RenJi Hosp,Sch Med, Shanghai, Peoples R China;
4.Univ Chinese Acad Sci, Shanghai, Peoples R China;
5.Minist Hlth, Key Lab Food Safety Risk Assessment, Beijing, Peoples R China;
6.Chinese Acad Sci, Mass Spectrometry Res Ctr, Inst Nutr Sci, Shanghai Inst Biol Sci, Shanghai, Peoples R China;
7.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China,
推荐引用方式
GB/T 7714		 Huang, Rong,Li, Shengxian,Wang, Yuying,et al. Alterations of polyunsaturated fatty acid metabolism in ovarian tissues of polycystic ovary syndrome rats[J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,2018,22(7):3388-3396.
APA Huang, Rong.,Li, Shengxian.,Wang, Yuying.,Liu, Wei.,Tao, Tao.,...&,.(2018).Alterations of polyunsaturated fatty acid metabolism in ovarian tissues of polycystic ovary syndrome rats.JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,22(7),3388-3396.
MLA Huang, Rong,et al."Alterations of polyunsaturated fatty acid metabolism in ovarian tissues of polycystic ovary syndrome rats".JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 22.7(2018):3388-3396.

入库方式： OAI收割

来源：上海营养与健康研究所

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