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Effects of Geniposide from Gardenia Fruit Pomace on Skeletal-Muscle Fibrosis

文献类型：期刊论文

作者Pan, Haiou3; Li, Yan3; Qian, Haifeng3; Qi, Xiguang3; Wu, Gangcheng3; Zhang, Hui3; Wang, Li3; Li, Yan2; Ying, Hao2; Xu, Meijuan1
刊名JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
出版日期2018
卷号66期号:23页码:5802-5811
ISSN号0021-8561
关键词gardenia fruit pomace geniposide skeletal-muscle fibrosis TGF-beta Smad4
DOI10.1021/acs.jafc.8b00739
文献子类Article
英文摘要Geniposide is the main bioactive constituent of gardenia fruit. Skeletal-muscle fibrosis is a common and irreversibly damaging process. Numerous studies have shown that geniposide could improve many chronic diseases, including metabolic syndrome and tumors. However, the effects of geniposide on skeletal-muscle fibrosis are still poorly understood. Here, we found that crude extracts of gardenia fruit pomace could significantly decrease the expression of profibrotic genes in vitro. Moreover, geniposide could also reverse profibrotic-gene expression induced by TGF-beta and Smad4, a regulator of skeletal-muscle fibrosis. In addition, geniposide treatment could significantly downregulate profibrotic-gene expression and improve skeletal muscle injuries in a mouse model of contusion. These results together suggest that geniposide has an antifibrotic effect on skeletal muscle through the suppression of the TGF-beta Smad4 signaling pathway.
学科主题Agriculture ; Chemistry ; Food Science & Technology
WOS关键词JASMINOIDES ELLIS ; TGF-BETA/SMAD ; MYOCARDIAL FIBROSIS ; IRIDOID GLYCOSIDES ; SIGNALING PATHWAY ; HEPATIC-FIBROSIS ; ACUTE CONTUSION ; LIVER FIBROSIS ; INJURY ; RATS
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:000435525800009
版本出版稿
源URL[http://202.127.25.144/handle/331004/537]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Jiangnan Univ, Sch Biotechnol, Lab Appl Microorganisms & Metab Engn, Key Lab Ind Biotechnol,Minist Educ, Wuxi 214122, Peoples R China;
2.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Food Safety Res,Inst Nutr Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China;
3.Jiangnan Univ, Sch Food Sci & Technol, State Key Lab Food Sci & Technol, Lihu Ave 1800, Wuxi 214122, Peoples R China;
4.Nantong Univ, Sch Pharm, Nantong 226001, Peoples R China,
推荐引用方式
GB/T 7714		 Pan, Haiou,Li, Yan,Qian, Haifeng,et al. Effects of Geniposide from Gardenia Fruit Pomace on Skeletal-Muscle Fibrosis[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2018,66(23):5802-5811.
APA Pan, Haiou.,Li, Yan.,Qian, Haifeng.,Qi, Xiguang.,Wu, Gangcheng.,...&,.(2018).Effects of Geniposide from Gardenia Fruit Pomace on Skeletal-Muscle Fibrosis.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,66(23),5802-5811.
MLA Pan, Haiou,et al."Effects of Geniposide from Gardenia Fruit Pomace on Skeletal-Muscle Fibrosis".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 66.23(2018):5802-5811.

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来源：上海营养与健康研究所

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