Triosephosphate isomerase 1 suppresses growth, migration and invasion of hepatocellular carcinoma cells
文献类型：期刊论文
| 作者 | Jiang, Hao3; Wei, Dongzhi3; Ma, Ning2; Shang, Yurong2; Chen, Tianwei2; Guan, Dongxian2; Li, Jingjing2; Wang, Jingjing2; Zhang, Erbin2; Feng, Yuanyuan2 |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2017 |
| 卷号 | 482期号:4页码:1048-1053 |
| 关键词 | TPI1 HCC Growth Migration Invasion Cell cycle |
| ISSN号 | 0006-291X |
| DOI | 10.1016/j.bbrc.2016.11.156 |
| 文献子类 | Article |
| 英文摘要 | Metabolic dysregulation is one of the most common and recognizable features of cancer. Triosephosphate isomerase 1 (TPI1), which catalyzes the interconversion of dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) during giycosis and gluconeogenesis, is a crucial enzyme in the carbohydrate metabolism. However, the biological function and mechanism of TPI1 in cancer remain largely unknown. In this study, we have found that TPI1 expression was greatly decreased in clinical HCC samples, positively correlated with overall survival, and negatively associated with histological differentiation, tumor size and organ metastasis. Forced expression of TPI1 in HCC cells inhibited cell growth, migration, and invasion in vitro. Consistently, knockdown of TPI1 by shRNA promoted cell growth, migration and invasion. Moreover, overexpression of TPI1 led to slowed tumor growth and decreased tumor weight in vivo. Furthermore, cell cycle arrest was induced by TPI1 over expression. These phenotypes were associated with altered expression of beta-catenin, Vimentin, P53, P27 and CyclinD1. Therefore, our data suggested that TPI1 functioned as a tumor suppressor in HCC and might serve as a potential therapeutic target for the treatment of HCC. (C) 2016 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Biophysics |
| WOS关键词 | CANCER-CELLS ; BETA-CATENIN ; EXPRESSION ; METASTASIS ; GLYCOLYSIS ; METABOLISM ; SURVIVAL ; P53 |
| 语种 | 英语 |
| WOS记录号 | WOS:000393720000081 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/539]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Fudan Univ, Zhongshan Hosp, Dept Gen Surg, Shanghai, Peoples R China, 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China; 3.East China Univ Sci & Technol, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Jiang, Hao,Wei, Dongzhi,Ma, Ning,et al. Triosephosphate isomerase 1 suppresses growth, migration and invasion of hepatocellular carcinoma cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2017,482(4):1048-1053. |
| APA | Jiang, Hao.,Wei, Dongzhi.,Ma, Ning.,Shang, Yurong.,Chen, Tianwei.,...&,.(2017).Triosephosphate isomerase 1 suppresses growth, migration and invasion of hepatocellular carcinoma cells.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,482(4),1048-1053. |
| MLA | Jiang, Hao,et al."Triosephosphate isomerase 1 suppresses growth, migration and invasion of hepatocellular carcinoma cells".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 482.4(2017):1048-1053. |
入库方式： OAI收割
来源：上海营养与健康研究所
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