Associations Between Linoleic Acid Intake and Incident Type 2 Diabetes Among US Men and Women
文献类型：期刊论文
| 作者 | Zong, Geng1,7; Liu, Gang7; Willett, Walter C.7; Hu, Frank B.4,5,6,7; Sun, Qi4,5,7; Willett, Walter C.4,5,6; Wanders, Anne J.3; Alssema, Marjan3; Zock, Peter L.3; Alssema, Marjan2 |
| 刊名 | DIABETES CARE
 |
| 出版日期 | 2019 |
| 卷号 | 42期号:8页码:1406-1413 |
| ISSN号 | 0149-5992 |
| DOI | 10.2337/dc19-0412 |
| 文献子类 | Article |
| 英文摘要 | OBJECTIVE To investigate the association between intakes of n-6 polyunsaturated fatty acids (PUFAs) and type 2 diabetes risk in three prospective cohort studies of U.S. men and women. RESEARCH DESIGN AND METHODS We followed 83,648 women from the Nurses' Health Study (NHS) (1980-2012), 88,610 women from NHSII (1991-2013), and 41,771 men from the Health Professionals Follow-Up Study (HPFS) (1986-2012). Dietary data were collected every 2-4 years by using validated food-frequency questionnaires. Self-reported incident diabetes, identified biennially, was confirmed by using a validated supplementary questionnaire. RESULTS During 4.93 million person-years of follow-up, 18,442 type 2 diabetes cases were documented. Dietary n-6 PUFAs accounted for 4.4-6.8% of total energy, on average, and consisted primarily of linoleic acid (LA) (>= 98%). In multivariate-adjusted models, hazard ratios (95% CIs) of type 2 diabetes risk comparing extreme n-6 PUFA quintiles (highest vs. lowest) were 0.91 (0.85, 0.96) (P-trend = 0.002) for total n-6 PUFAs and 0.92 (0.87, 0.98) (P-trend = 0.01) for LA. In an isocaloric substitution model, diabetes risk was 14% (95% CI 5%, 21%) (P = 0.002) lower when LA isocalorically replaced saturated fats (5% of energy), 17% (95% CI 9%, 24%) (P < 0.001) lower for trans fats (2% of energy), or 9% (95% CI 17%, 0.1%) (P = 0.047) lower for carbohydrates (5% of energy). Replacing n-3 PUFAs or monounsaturated fats with LA was not significantly associated with type 2 diabetes risk. CONCLUSIONS Our study provides additional evidence that LA intake is inversely associated with risk of type 2 diabetes, especially when replacing saturated fatty acids, trans fats, or carbohydrates. |
| 学科主题 | Endocrinology & Metabolism |
| WOS关键词 | CORONARY-HEART-DISEASE ; DIETARY FATTY-ACIDS ; PHYSICAL-ACTIVITY ; ARACHIDONIC-ACID ; SATURATED FAT ; RISK ; QUESTIONNAIRE ; MELLITUS ; CONSUMPTION ; VALIDITY |
| 语种 | 英语 |
| WOS记录号 | WOS:000476786200012 |
| 出版者 | AMER DIABETES ASSOC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/545]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Key Lab Nutr Metab & Food Safety,Inst Nutr &, Shanghai, Peoples R China; 2.Vrije Univ Amsterdam Med Ctr, Dept Epidemiol & Biostat, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands, 3.Unilever Res Labs, Vlaardingen, Netherlands; 4.Harvard Med Sch, Boston, MA 02115 USA; 5.Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA; 6.Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA; 7.Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA; |
| 推荐引用方式 GB/T 7714 | Zong, Geng,Liu, Gang,Willett, Walter C.,et al. Associations Between Linoleic Acid Intake and Incident Type 2 Diabetes Among US Men and Women[J]. DIABETES CARE,2019,42(8):1406-1413. |
| APA | Zong, Geng.,Liu, Gang.,Willett, Walter C..,Hu, Frank B..,Sun, Qi.,...&Alssema, Marjan.(2019).Associations Between Linoleic Acid Intake and Incident Type 2 Diabetes Among US Men and Women.DIABETES CARE,42(8),1406-1413. |
| MLA | Zong, Geng,et al."Associations Between Linoleic Acid Intake and Incident Type 2 Diabetes Among US Men and Women".DIABETES CARE 42.8(2019):1406-1413. |
入库方式： OAI收割
来源：上海营养与健康研究所
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