Expression profile of circular RNAs in myocardial ischemia/reperfusion with and without intermittent hypobaric hypoxia preconditioning
文献类型：期刊论文
| 作者 | Tan, Jiliang1,2; Gu, Shanshan1,2; Zheng, Yanjun1,2; Yang, Huangtian1,2; , |
| 刊名 | SCIENCE CHINA-LIFE SCIENCES
 |
| 出版日期 | 2019 |
| 卷号 | 62期号:8页码:1104-1106 |
| ISSN号 | 1674-7305 |
| DOI | 10.1007/s11427-018-9478-0 |
| 文献子类 | Letter |
| 英文摘要 | Stat6 is known to drive macrophage M2 polarization. However, how macrophage polarization is fine-tuned by Stat6 is poorly understood. Here, we find that Lys383 of Stat6 is acetylated by the acetyltransferase CREB-binding protein (CBP) during macrophage activation to suppress macrophage M2 polarization. Mechanistically, Trim24, a CBP-associated E3 ligase, promotes Stat6 acetylation by catalyzing CBP ubiquitination at Lys119 to facilitate the recruitment of CBP to Stat6. Loss of Trim24 inhibits Stat6 acetylation and thus promotes M2 polarization in both mouse and human macrophages, potentially compromising antitumor immune responses. By contrast, Stat6 mediates the suppression of TRIM24 expression in M2 macrophages to contribute to the induction of an immunosuppressive tumor niche. Taken together, our findings establish Stat6 acetylation as an essential negative regulatory mechanism that curtails macrophage M2 polarization. |
| 学科主题 | Life Sciences & Biomedicine - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000481780500014 |
| 出版者 | SCIENCE PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/546]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China, 2.Chinese Acad Sci, CAS Key Lab Tissue Microenvironm & Tumor, Shanghai Inst Nutr & Hlth, Lab Mol Cardiol,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Tan, Jiliang,Gu, Shanshan,Zheng, Yanjun,et al. Expression profile of circular RNAs in myocardial ischemia/reperfusion with and without intermittent hypobaric hypoxia preconditioning[J]. SCIENCE CHINA-LIFE SCIENCES,2019,62(8):1104-1106. |
| APA | Tan, Jiliang,Gu, Shanshan,Zheng, Yanjun,Yang, Huangtian,&,.(2019).Expression profile of circular RNAs in myocardial ischemia/reperfusion with and without intermittent hypobaric hypoxia preconditioning.SCIENCE CHINA-LIFE SCIENCES,62(8),1104-1106. |
| MLA | Tan, Jiliang,et al."Expression profile of circular RNAs in myocardial ischemia/reperfusion with and without intermittent hypobaric hypoxia preconditioning".SCIENCE CHINA-LIFE SCIENCES 62.8(2019):1104-1106. |
入库方式： OAI收割
来源：上海营养与健康研究所
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