PHF7 is a novel histone H2A E3 ligase prior to histone-to-protamine exchange during spermiogenesis
文献类型：期刊论文
| 作者 | Wang, Xiukun2; Wei, Leixin2; Yang, Suming2; Lu, Lei2; Yan, Meng2; Bai, Meizhu2; Li, Na2; Li, Jinsong2; Kang, Jun-Yan5; Liu, Mo-Fang5 |
| 刊名 | DEVELOPMENT
 |
| 出版日期 | 2019 |
| 卷号 | 146期号:13页码:UNSP dev175547 |
| 关键词 | Spermiogenesis Histone-to-protamine exchange PHF7 Histone H2A ubiquitylation E3 ligase |
| ISSN号 | 0950-1991 |
| DOI | 10.1242/dev.175547 |
| 文献子类 | Article |
| 英文摘要 | Epigenetic regulation, including histone-to-protamine exchanges, controls spermiogenesis. However, the underlying mechanisms of this regulation are largely unknown. Here, we report that PHF7, a testis-specific PHD and RING finger domain-containing protein, is essential for histone-to-protamine exchange in mice. PHF7 is specifically expressed during spermiogenesis. PHF7 deletion results in male infertility due to aberrant histone retention and impaired protamine replacement in elongated spermatids. Mechanistically, PHF7 can simultaneously bind histone H2A and H3; its PHD domain, a histone code reader, can specifically bind H3K4me3/me2, and its RING domain, a histone writer, can ubiquitylate H2A. Thus, our study reveals that PHF7 is a novel E3 ligase that can specifically ubiquitylate H2A through binding H3K4me3/me2 prior to histone-to-protamine exchange. |
| 学科主题 | Developmental Biology |
| WOS关键词 | ROUND SPERMATID INJECTION ; DNA-DAMAGE ; CELLS ; UBIQUITINATION ; MICE ; INFERTILITY ; TRANSITION ; GENERATION ; PROTEINS ; SERTOLI |
| 语种 | 英语 |
| WOS记录号 | WOS:000475477400018 |
| 出版者 | COMPANY BIOLOGISTS LTD |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/548]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Second Mil Med Univ, Changzheng Hosp, Dept Orthopaed Surg, Shanghai 200003, Peoples R China; 2.Univ Chinese Acad Sci, Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci,Shanghai Key Lab, Inst Biochem & Cell Biol,State Key Lab Cell Biol, Shanghai 200031, Peoples R China; 3.Chinese Acad Sci, CAS MPG Partner Inst Computat Biol, Shanghai Inst Biol Sci, Key Lab Computat Biol, Shanghai 200031, Peoples R China; 4.Guangxi Univ, State Key Lab Conservat & Utilizat Subtrop Agrobi, Anim Reprod Inst, Nanning 530004, Guangxi, Peoples R China; 5.Univ Chinese Acad Sci, Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Inst Biochem & Cell Biol,State Key Lab Mol Biol,S, Shanghai 200031, Peoples R China; 6.Chinese Acad Sci, Natl Ctr Prot Sci Shanghai, Inst Biochem & Cell Biol, 333 Haike Rd, Shanghai 201203, Peoples R China; 7.Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China; 8.Chinese Acad Agr Sci, Res Ctr Anim Genom, Agr Genom Inst Shengzhen, Shengzhen 518210, Guangdong, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Wang, Xiukun,Wei, Leixin,Yang, Suming,et al. PHF7 is a novel histone H2A E3 ligase prior to histone-to-protamine exchange during spermiogenesis[J]. DEVELOPMENT,2019,146(13):UNSP dev175547. |
| APA | Wang, Xiukun.,Wei, Leixin.,Yang, Suming.,Lu, Lei.,Yan, Meng.,...&,.(2019).PHF7 is a novel histone H2A E3 ligase prior to histone-to-protamine exchange during spermiogenesis.DEVELOPMENT,146(13),UNSP dev175547. |
| MLA | Wang, Xiukun,et al."PHF7 is a novel histone H2A E3 ligase prior to histone-to-protamine exchange during spermiogenesis".DEVELOPMENT 146.13(2019):UNSP dev175547. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。