Dietary fats and mortality among patients with type 2 diabetes: analysis in two population based cohort studies
文献类型：期刊论文
| 作者 | Jiao, Jingjing8,9; Liu, Gang9; Hu, Frank B.9; Rimm, Eric B.3,4,5,9; Zong, Geng9; Sun, Qi4,5,9; Zong, Geng2; Shin, Hyun Joon1; Hu, Frank B.3,4,5; Manson, JoAnn E.3,4,5,6,7 |
| 刊名 | BMJ-BRITISH MEDICAL JOURNAL
 |
| 出版日期 | 2019 |
| 卷号 | 366期号:-页码:l4009 |
| 关键词 | lncRNA rice heading date yield |
| ISSN号 | 1756-1833 |
| DOI | 10.1136/bmj.l4009 |
| 文献子类 | Article |
| 英文摘要 | OBJECTIVE To assess the association of dietary fatty acids with cardiovascular disease mortality and total mortality among patients with type 2 diabetes. DESIGN Prospective, longitudinal cohort study. SETTING Health professionals in the United States. PARTICIPANTS 11 264 participants with type 2 diabetes in the Nurses' Health Study (1980-2014) and Health Professionals Follow-Up Study (1986-2014). EXPOSURE Dietary fat intake assessed using validated food frequency questionnaires and updated every two to four years. MAIN OUTCOME MEASURE Total and cardiovascular disease mortality during follow-up. RESULTS During follow-up, 2502 deaths including 646 deaths due to cardiovascular disease were documented. After multivariate adjustment, intake of polyunsaturated fatty acids (PUFAs) was associated with a lower cardiovascular disease mortality, compared with total carbohydrates: hazard ratios comparing the highest with the lowest quarter were 0.76 (95% confidence interval 0.58 to 0.99; P for trend=0.03) for total PUFAs, 0.69 (0.52 to 0.90; P=0.007) for marine n-3 PUFAs, 1.13 (0.85 to 1.51) for a-linolenic acid, and 0.75 (0.56 to 1.01) for linoleic acid. Inverse associations with total mortality were also observed for intakes of total PUFAs, n-3 PUFAs, and linoleic acid, whereas monounsaturated fatty acids of animal, but not plant, origin were associated with a higher total mortality. In models that examined the theoretical effects of substituting PUFAs for other fats, isocalorically replacing 2% of energy from saturated fatty acids with total PUFAs or linoleic acid was associated with 13% (hazard ratio 0.87, 0.77 to 0.99) or 15% (0.85, 0.73 to 0.99) lower cardiovascular disease mortality, respectively. A 2% replacement of energy from saturated fatty acids with total PUFAs was associated with 12% (hazard ratio 0.88, 0.83 to 0.94) lower total mortality. CONCLUSIONS In patients with type 2 diabetes, higher intake of PUFAs, in comparison with carbohydrates or saturated fatty acids, is associated with lower total mortality and cardiovascular disease mortality. These findings highlight the important role of quality of dietary fat in the prevention of cardiovascular disease and total mortality among adults with type 2 diabetes. |
| 学科主题 | General & Internal Medicine |
| WOS关键词 | CORONARY-HEART-DISEASE ; CARDIOVASCULAR-DISEASE ; PHYSICAL-ACTIVITY ; LIFE-STYLE ; LINOLEIC-ACID ; RISK ; MELLITUS ; OMEGA-3-FATTY-ACIDS ; PREVENTION ; REPRODUCIBILITY |
| 语种 | 英语 |
| WOS记录号 | WOS:000474835400001 |
| 出版者 | BMJ PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/551]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Harvard Med Sch, Brigham & Womens Hosp, Dept Global Hlth & Social Med, Div Gen Internal Med,Div Global Hlth Equ,Dept Med, Boston, MA 02115 USA; 2.Univ Chinese Acad Sci, Chinese Acad Sci, CAS Key Lab Nutr Metab & Food Safety, Inst Nutr & Hlth,Shanghai Inst Biol Sci, Shanghai, Peoples R China; 3.Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA; 4.Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA; 5.Harvard Med Sch, Boston, MA 02115 USA; 6.Brigham & Womens Hosp, Dept Med, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA; 7.Brigham & Womens Hosp, Dept Med, Div Womens Hlth, 75 Francis St, Boston, MA 02115 USA, 8.Zhejiang Univ, Sch Med, Sch Publ Hlth, Dept Nutr, Hangzhou, Zhejiang, Peoples R China; 9.Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA; |
| 推荐引用方式 GB/T 7714 | Jiao, Jingjing,Liu, Gang,Hu, Frank B.,et al. Dietary fats and mortality among patients with type 2 diabetes: analysis in two population based cohort studies[J]. BMJ-BRITISH MEDICAL JOURNAL,2019,366(-):l4009. |
| APA | Jiao, Jingjing.,Liu, Gang.,Hu, Frank B..,Rimm, Eric B..,Zong, Geng.,...&,.(2019).Dietary fats and mortality among patients with type 2 diabetes: analysis in two population based cohort studies.BMJ-BRITISH MEDICAL JOURNAL,366(-),l4009. |
| MLA | Jiao, Jingjing,et al."Dietary fats and mortality among patients with type 2 diabetes: analysis in two population based cohort studies".BMJ-BRITISH MEDICAL JOURNAL 366.-(2019):l4009. |
入库方式： OAI收割
来源：上海营养与健康研究所
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