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Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses

文献类型：期刊论文

作者Jiang, Yuhang2,3; Li, Cuifeng2,3; Chen, Xi2,3; Liu, Hanshao2,3; Liu, Zhi2,3; Sun, Xiaohua2,3; Hu, Yiming2,3; Zhang, Xiaoren2,3; Liu, Sanhong3; Zhan, Yu3
刊名NATURE COMMUNICATIONS
出版日期2019
卷号10期号:-页码:2935
ISSN号2041-1723
DOI10.1038/s41467-019-11002-5
文献子类Article
英文摘要Trace elements play important roles in human health, but little is known about their functions in humoral immunity. Here, we show an important role for iron in inducing cyclin E and B cell proliferation. We find that iron-deficient individuals exhibit a significantly reduced antibody response to the measles vaccine when compared to iron-normal controls. Mice with iron deficiency also exhibit attenuated T-dependent or T-independent antigen-specific antibody responses. We show that iron is essential for B cell proliferation; both iron deficiency and a-ketoglutarate inhibition could suppress cyclin E1 induction and S phase entry of B cells upon activation. Finally, we demonstrate that three demethylases, KDM2B, KDM3B and KDM4C, are responsible for histone 3 lysine 9 (H3K9) demethylation at the cyclin E1 promoter, cyclin E1 induction and B cell proliferation. Thus, our data reveal a crucial role of H3K9 demethylation in B cell proliferation, and the importance of iron in humoral immunity.
学科主题Science & Technology - Other Topics
WOS关键词VACCINE FAILURE ; DEFICIENCY ; MICE ; DIFFERENTIATION ; METHYLATION ; MECHANISMS ; PROTEINS ; MUTATION ; SUBSETS ; MEASLES
语种英语
WOS记录号WOS:000473622200005
出版者NATURE PUBLISHING GROUP
版本出版稿
源URL[http://202.127.25.144/handle/331004/553]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Zhejiang Prov Ctr Dis Control & Prevent, Hangzhou 310051, Zhejiang, Peoples R China;
2.Guangzhou Med Univ, Affiliated Canc Hosp & Inst, Guangzhou 510000, Guangdong, Peoples R China;
3.Univ Chinese Acad Sci, Chinese Acad Sci, CAS Key Lab Tissue Microenvironm & Tumor, Shanghai Inst Nutr & Hlth,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China;
4.Zhejiang Univ, Inst Translat Med, Sch Publ Hlth, Affiliated Hosp 1,Sch Med, Hangzhou 310058, Zhejiang, Peoples R China;
5.Wannan Med Coll, Affiliated Hosp 1, Dept Hematol, Wuhu 241000, Peoples R China;
6.Zhengzhou Univ, Sch Publ Hlth, Dept Nutr, Precis Nutr Innovat Ctr, Zhengzhou 450001, Henan, Peoples R China;
7.Univ Chinese Acad Sci, Chinese Acad Sci, Max Planck Partner Inst Computat Biol, Key Lab Computat Biol,Shanghai Inst Nutr & Hlth, Shanghai 200031, Peoples R China;
8.Fudan Univ, Zhongshan Hosp, Dept Hematol, Shanghai 200032, Peoples R China;
9.Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Shanghai Key Lab Orthopaed Implants,Dept Orthopae, Shanghai 200011, Peoples R China,
10.Shanghai Jiao Tong Univ, Sch Med, Shanghai Canc Inst, Shanghai 200240, Peoples R China;
推荐引用方式
GB/T 7714		 Jiang, Yuhang,Li, Cuifeng,Chen, Xi,et al. Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses[J]. NATURE COMMUNICATIONS,2019,10(-):2935.
APA Jiang, Yuhang.,Li, Cuifeng.,Chen, Xi.,Liu, Hanshao.,Liu, Zhi.,...&Hao, Yongqiang.(2019).Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses.NATURE COMMUNICATIONS,10(-),2935.
MLA Jiang, Yuhang,et al."Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses".NATURE COMMUNICATIONS 10.-(2019):2935.

入库方式： OAI收割

来源：上海营养与健康研究所

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