Mouse models for human hyperuricaemia: a critical review
文献类型：期刊论文
| 作者 | Lu, Jie4,5; Wei, Wen-Hua5; Li, Changgui4; Dalbeth, Nicola3; Yin, Huiyong2; Merriman, Tony R.1; , |
| 刊名 | NATURE REVIEWS RHEUMATOLOGY
 |
| 出版日期 | 2019 |
| 卷号 | 15期号:7页码:413-426 |
| ISSN号 | 1759-4790 |
| DOI | 10.1038/s41584-019-0222-x |
| 文献子类 | Review |
| 英文摘要 | Hyperuricaemia (increased serum urate concentration) occurs mainly in higher primates, including in humans, because of inactivation of the gene encoding uricase during primate evolution. Individuals with hyperuricaemia might develop gout - a painful inflammatory arthritis caused by monosodium urate crystal deposition in articular structures. Hyperuricaemia is also associated with common chronic diseases, including hypertension, chronic kidney disease, type 2 diabetes and cardiovascular disease. Many mouse models have been developed to investigate the causal mechanisms for hyperuricaemia. These models are highly diverse and can be divided into two broad categories: mice with genetic modifications (genetically induced models) and mice exposed to certain environmental factors (environmentally induced models; for example, pharmaceutical or dietary induction). This Review provides an overview of the mouse models of hyperuricaemia and the relevance of these models to human hyperuricaemia, with an emphasis on those models generated through genetic modifications. The challenges in developing and comparing mouse models of hyperuricaemia and future research directions are also outlined. |
| 学科主题 | Rheumatology |
| WOS关键词 | SERUM URIC-ACID ; OXONATE-INDUCED HYPERURICEMIA ; XANTHINE-OXIDASE INHIBITOR ; URATE-OXIDASE ; PRIMATE EVOLUTION ; OXIDATIVE STRESS ; KIDNEY-FUNCTION ; GOUT ; MICE ; INFLAMMATION |
| 语种 | 英语 |
| WOS记录号 | WOS:000472752900011 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/555]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Otago, Dept Biochem, Dunedin, New Zealand, 2.Chinese Acad Sci, Key Lab Nutr Metab & Food Safety, Shanghai Inst Nutr & Hlth, SIBS, Shanghai, Peoples R China; 3.Univ Auckland, Dept Med, Auckland, New Zealand; 4.Qingdao Univ, Affiliated Hosp, Inst Metab Dis, Shandong Prov Key Lab Metab Dis,Dept Endocrinol &, Qingdao, Shandong, Peoples R China; 5.Univ Otago, Dept Womens & Childrens Hlth, Dunedin, New Zealand; |
| 推荐引用方式 GB/T 7714 | Lu, Jie,Wei, Wen-Hua,Li, Changgui,et al. Mouse models for human hyperuricaemia: a critical review[J]. NATURE REVIEWS RHEUMATOLOGY,2019,15(7):413-426. |
| APA | Lu, Jie.,Wei, Wen-Hua.,Li, Changgui.,Dalbeth, Nicola.,Yin, Huiyong.,...&,.(2019).Mouse models for human hyperuricaemia: a critical review.NATURE REVIEWS RHEUMATOLOGY,15(7),413-426. |
| MLA | Lu, Jie,et al."Mouse models for human hyperuricaemia: a critical review".NATURE REVIEWS RHEUMATOLOGY 15.7(2019):413-426. |
入库方式： OAI收割
来源：上海营养与健康研究所
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