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A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling

文献类型：期刊论文

作者Li, Weiping10; He, Qiang10; Hu, Chaobo10; Zhu, Linying10; Ma, Xiaolong10; Ma, Xueyan10; Bao, Shujie10; Li, Lu10; Chen, Yingying10; Cen, Jin10
刊名CELL STEM CELL
出版日期2019
卷号25期号:1页码:54-+
关键词Berberine Nonalcoholic fatty liver disease NAFLD Stearyl-coenzyme A desaturase 1 SCD1 Sterol regulatory element-binding protein-1c SREBP-1c AMP-activated protein kinase AMPK
ISSN号1934-5909
DOI10.1016/j.stem.2019.06.008
文献子类Article
英文摘要Following injury, differentiated epithelial cells can serve as a stem cell-independent source for tissue regeneration by undergoing reprogramming into other cell types. The intrinsic molecular basis underlying plasticity of differentiated cells remains largely unaddressed. Here we show that Arid1a, a key component of the SWI/SNF chromatin remodeling complex, controls liver regeneration and gene expression associated with emergence of injury-induced liver-progenitor-like cells (LPLCs). Hepatocyte-specific Arid1a ablation reduces LPLC gene expression in several models of periportal liver injury and impairs liver regeneration, leading to organ dysfunction. Arid1a establishes a permissive chromatin state at LPLC-enriched genes during homeostasis, suggesting it endows hepatocytes with competence to respond to injury-induced signals. Consistently, Arid1a facilitates binding of YAP, a critical regeneration signaling pathway, to LPLC-enriched genes, and Arid1a deletion prevents their YAP-associated induction following injury. Together, these findings provide a framework for studying the contributions of injury-induced LPLCs to periportal liver regeneration.
学科主题Cell Biology
WOS关键词STEM-CELLS ; SWI/SNF COMPLEX ; ATAC-SEQ ; MECHANISMS ; GENE ; EXPRESSION ; PLASTICITY ; ALPHA ; PLURIPOTENCY ; REGENERATION
语种英语
WOS记录号WOS:000473770700008
出版者CELL PRESS
版本出版稿
源URL[http://202.127.25.144/handle/331004/561]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Univ Michigan, Cardiovasc Res Ctr, Dept Cardiac Surg, Ann Arbor, MI 48109 USA;
2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China,
3.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Biores Innovat Ctr, Suzhou 215121, Peoples R China;
4.Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China;
5.Second Mil Med Univ, Changzheng Hosp, Dept Gastroenterol, Shanghai 200003, Peoples R China;
6.Shanghai Acad Sci & Technol, Shanghai Ctr Bioinformat Technol, Shanghai 201203, Peoples R China;
7.Fudan Univ, Collaborat Innovat Ctr Genet & Dev, Shanghai 200433, Peoples R China;
8.Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China;
9.Chinese Acad Sci, CAS MPG Partner Inst Computat Biol, CAS Key Lab Computat Biol,Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China;
10.Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Cell Biol,Univ Chinese Acad Sci, Shanghai 200031, Peoples R China;
推荐引用方式
GB/T 7714		 Li, Weiping,He, Qiang,Hu, Chaobo,et al. A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling[J]. CELL STEM CELL,2019,25(1):54-+.
APA Li, Weiping.,He, Qiang.,Hu, Chaobo.,Zhu, Linying.,Ma, Xiaolong.,...&,.(2019).A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling.CELL STEM CELL,25(1),54-+.
MLA Li, Weiping,et al."A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling".CELL STEM CELL 25.1(2019):54-+.

入库方式： OAI收割

来源：上海营养与健康研究所

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