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Elevated serum neuregulin 4 levels in patients with hyperthyroidism

文献类型：期刊论文

作者Li, Min2; Chen, Ying2; Jiang, Jingjing2; Lu, Yan2; Zhao, Lin2; Song, Zhiyi3; Zhang, Shengjie4; Sun, Chao4; Ying, Hao4; Fan, Xiaofang1
刊名ENDOCRINE CONNECTIONS
出版日期2019
卷号8期号:6页码:728-735
关键词thyroid metabolism
ISSN号2049-3614
DOI10.1530/EC-19-0175
文献子类Article
英文摘要Objective: Recent studies have shown that neuregulin 4 (Nrg4), a member of the epidermal growth factor (EGF) family of extracellular ligands, plays an important role in the prevention of obesity, insulin resistance and nonalcoholic fatty liver disease (NAFLD). Considering that thyroid hormone (TH) has profound effects on whole-body energy metabolism, we speculate that circulating Nrg4 levels might be altered in patients with hyperthyroidism. Design and methods: A total of 129 hyperthyroid patients and 100 healthy subjects were recruited. Of them, 39 hyperthyroid patients received thionamide treatment for 3 months until euthyroidism. Serum Nrg4 levels were determined using the ELISA method. To further confirm the relationship between TH and Nrg4, C57BL/6 mice were treated with T-3 and quantitative real-time PCR was performed to detect Nrg4 gene expression. Results: Serum Nrg4 levels were significantly elevated in hyperthyroid patients as compared with normal controls (3.84 +/- 1.63 vs 2.21 +/- 1.04 ng/mL, P < 0.001). After achieving euthyroidism by thionamide treatment, serum Nrg4 levels dropped markedly from 3.57 +/- 1.26 to 1.94 +/- 0.72 ng/ml (P < 0.001). After adjustment for potential confounders, serum Nrg4 levels were independently associated with hyperthyroidism. The upregulation of Nrg4 expression in the livers and white adipose tissues by T-3 was further confirmed by animal and cell culture experiments. Conclusions: Serum Nrg4 levels were increased in patients with hyperthyroidism. The liver and white adipose tissue might be primary sources contributing to elevated serum Nrg4 concentrations.
学科主题Endocrinology & Metabolism
WOS关键词THYROID-HORMONE REGULATION ; TYPE-2 DIABETES-MELLITUS ; GROWTH-FACTOR 21 ; HEPATIC STEATOSIS ; NRG4 ; PROTEIN ; LIVER
语种英语
WOS记录号WOS:000472586000013
出版者BIOSCIENTIFICA LTD
版本出版稿
源URL[http://202.127.25.144/handle/331004/566]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Fudan Univ, Shanghai Minhang Hosp, Cent Hosp Minhang Dist, Dept Endocrinol & Metab,Minhang Branch,Zhongshan, Shanghai, Peoples R China,
2.Fudan Univ, Zhongshan Hosp, Fudan Inst Metab Dis, Dept Endocrinol & Metab, Shanghai, Peoples R China;
3.Shanghai Jiao Tong Univ, Sch Med, Shanghai Gen Hosp, Dept Endocrinol & Metab, Shanghai, Peoples R China;
4.Univ Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Key Lab Nutr Metab & Food Safety, Shanghai, Peoples R China;
推荐引用方式
GB/T 7714		 Li, Min,Chen, Ying,Jiang, Jingjing,et al. Elevated serum neuregulin 4 levels in patients with hyperthyroidism[J]. ENDOCRINE CONNECTIONS,2019,8(6):728-735.
APA Li, Min.,Chen, Ying.,Jiang, Jingjing.,Lu, Yan.,Zhao, Lin.,...&,.(2019).Elevated serum neuregulin 4 levels in patients with hyperthyroidism.ENDOCRINE CONNECTIONS,8(6),728-735.
MLA Li, Min,et al."Elevated serum neuregulin 4 levels in patients with hyperthyroidism".ENDOCRINE CONNECTIONS 8.6(2019):728-735.

入库方式： OAI收割

来源：上海营养与健康研究所

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