Destabilization of AETFC through C/EBP alpha-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation
文献类型：期刊论文
| 作者 | Zhang, Meng-Meng4; Zhang, Yuan-Liang4; Wang, Xiao-Lin4; Xie, Yin-Yin4; Zhu, Jiang4; Chen, Zhu4; Chen, Sai-Juan4; Huang, Qiu-Hua4; Sun, Xiao-Jian4; Liu, Na5 |
| 刊名 | LEUKEMIA
 |
| 出版日期 | 2019 |
| 卷号 | 33期号:7页码:1822-1827 |
| 关键词 | TiO2 NPs intestinal inflammation gut flora immune response |
| ISSN号 | 0887-6924 |
| DOI | 10.1038/s41375-019-0398-8 |
| 文献子类 | Letter |
| 英文摘要 | Early stage exposure of foodborne substances, such as brightening agent titanium dioxide nanoparticles (TiO2 NPs), can cause long-term effects in adulthood. We aimed to explore the potential adverse effect of long-term dietary intake of TiO2 NPs. After feeding for 2-3 months from weaning, TiO2 NPs-exposed mice showed lower body weight and induced intestinal inflammation. However, this phenomenon was not observed in gut microbiota-removed mice. TiO2 NPs exposure rarely affected the diversity of microbial communities, but significantly decreased the abundance of several probiotic taxa including Bifidobacterium and Lactobacillus. Additionally, TiO2 NPs aggravated DSS-induced chronic colitis and immune response in vivo, and reduced the population of CD4+T cells, regulatory T cells, and macrophages in mesenteric lymph nodes. Therefore, dietary TiO2 NPs could interfere with the balance of immune system and dynamic of gut microbiome, which may result in low-grade intestinal inflammation and aggravated immunological response to external stimulus, thus introducing potential health risk. |
| 学科主题 | Oncology ; Hematology |
| WOS关键词 | TRANSCRIPTION FACTORS ; PROMISCUITY ; DEPLETION ; DISORDER ; AML |
| 语种 | 英语 |
| WOS记录号 | WOS:000473724900027 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/570]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Key Lab Pediat Hematol & Oncol, Dept Pediat Hematol & Oncol, Minist Hlth,Shanghai Childrens Med Ctr,Sch Med, Shanghai, Peoples R China; 2.Univ Miami, Miller Sch Med, Dept Biochem & Mol Biol, Dept Med,Sylvester Comprehens Canc Ctr, Miami, FL 33136 USA; 3.Rockefeller Univ, Lab Biochem & Mol Biol, 1230 York Ave, New York, NY 10021 USA, 4.Shanghai Jiao Tong Univ, Natl Res Ctr Translat Med, State Key Lab Med Genom, Shanghai Inst Hematol,Ruijin Hosp,Sch Med, Shanghai, Peoples R China; 5.Chinese Acad Sci, Univ Chinese Acad Sci, CAS Key Lab Tissue Microenvironm & Tumor, Shanghai Inst Nutr & Hlth,Shanghai Inst Biol Sci, Shanghai, Peoples R China; 6.Fudan Univ, Key Lab Carcinogenesis & Canc Invas, Key Lab Epigenet & Metab, Liver Canc Inst,Zhongshan Hosp,Minist Educ,Minist, Shanghai, Peoples R China; 7.Fudan Univ, Inst Biomed Sci, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Meng-Meng,Zhang, Yuan-Liang,Wang, Xiao-Lin,et al. Destabilization of AETFC through C/EBP alpha-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation[J]. LEUKEMIA,2019,33(7):1822-1827. |
| APA | Zhang, Meng-Meng.,Zhang, Yuan-Liang.,Wang, Xiao-Lin.,Xie, Yin-Yin.,Zhu, Jiang.,...&Roeder, Robert G..(2019).Destabilization of AETFC through C/EBP alpha-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation.LEUKEMIA,33(7),1822-1827. |
| MLA | Zhang, Meng-Meng,et al."Destabilization of AETFC through C/EBP alpha-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation".LEUKEMIA 33.7(2019):1822-1827. |
入库方式： OAI收割
来源：上海营养与健康研究所
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