Fibrotic liver microenvironment promotes Dll4 and SDF-1-dependent T-cell lineage development
文献类型：期刊论文
| 作者 | Gong, Zheng2,3; Shang, Bingxue2; Chu, Yunpeng2; Chen, Yongjing2; Shang, Qianwen2; Zheng, Zhiyuan2; Song, Lin2; Li, Yanan2; Liu, Rui2; Xu, Chenchang2 |
| 刊名 | CELL DEATH & DISEASE
 |
| 出版日期 | 2019 |
| 卷号 | 10期号:-页码:440 |
| ISSN号 | 2041-4889 |
| 关键词 | hepatitis myeloid-derive suppressor cells (MDSCs) TPL2 IL-25 chemokine |
| DOI | 10.1038/s41419-019-1630-1 |
| 文献子类 | Article |
| 英文摘要 | The reconstitution of the T-cell repertoire and quantity is a major challenge in the clinical management of HIV infection/AIDS, cancer, and aging-associated diseases. We previously showed that autologous bone marrow transfusion (BMT) via the hepatic portal vein could effectively restore CD4+ T-cell count in AIDS patients also suffering from decompensated liver cirrhosis. In the current study, we characterized T-cell reconstitution in a mouse model of liver fibrosis induced by CCl4 and found that T-cell reconstitution after BMT via hepatic portal vein was also greatly enhanced. The expression of Dll4 (Delta-like 4), which plays an important role in T-cell progenitor expansion, was elevated in hepatocytes of fibrotic livers when compared to normal livers. This upregulation of Dll4 expression was found to be induced by TNF alpha in an NF kappa B-dependent manner. Liver fibroblasts transfected with Dll4 (LF-Dll4) also gained the capacity to promote T-cell lineage development from hematopoietic stem cells (HSCs), resulting in the generation of DN2 (CD4 and CD8 DN 2) and DN3 T-cell progenitors in vitro, which underwent a normal maturation program when adoptively transferred into Rag-2 deficient hosts. We also demonstrated a pivotal role of SDF-1 produced by primary liver fibroblasts (primary LF) in T-lineage differentiation from HSCs. These results suggest that Dll4 and SDF-1 in fibrotic liver microenvironment could promote extrathymic T-cell lineage development. These results expand our knowledge of T-cell development and reconstitution under pathological conditions. |
| 学科主题 | Cell Biology |
| WOS关键词 | CHEMOKINE RECEPTOR CXCR4 ; IMMUNE RECONSTITUTION ; PROGENITOR CELLS ; DIFFERENTIATION ; LYMPHOPOIESIS ; MYELOPOIESIS ; MIGRATION ; RESPONSES ; THYMUS ; HIV-1 |
| 语种 | 英语 |
| 出版者 | NATURE PUBLISHING GROUP |
| WOS记录号 | WOS:000470936500003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/572]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Second Mil Med Univ, Changhai Hosp, Dept Gastroenterol, Shanghai, Peoples R China, 2.Soochow Univ, Med Coll, Inst Translat Med,Key Lab Stem Cells & Med Biomat, State Key Lab Radiat Med & Protect,Affiliated Hos, Suzhou, Peoples R China; 3.Univ Chinese Acad Sci, Chinese Acad Sci, Inst Hlth Sci, Shanghai Inst Biol Sci,Key Lab Tissue Microenviro, Shanghai, Peoples R China; 4.Fudan Univ, Dept Surg, Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Gong, Zheng,Shang, Bingxue,Chu, Yunpeng,et al. Fibrotic liver microenvironment promotes Dll4 and SDF-1-dependent T-cell lineage development[J]. CELL DEATH & DISEASE,2019,10(-):440. |
| APA | Gong, Zheng.,Shang, Bingxue.,Chu, Yunpeng.,Chen, Yongjing.,Shang, Qianwen.,...&,.(2019).Fibrotic liver microenvironment promotes Dll4 and SDF-1-dependent T-cell lineage development.CELL DEATH & DISEASE,10(-),440. |
| MLA | Gong, Zheng,et al."Fibrotic liver microenvironment promotes Dll4 and SDF-1-dependent T-cell lineage development".CELL DEATH & DISEASE 10.-(2019):440. |
入库方式： OAI收割
来源：上海营养与健康研究所
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