Trimethylamine N-oxide attenuates high-fat high-cholesterol diet-induced steatohepatitis by reducing hepatic cholesterol overload in rats
文献类型：期刊论文
| 作者 | Zhao, Ze-Hua3; Xin, Feng-Zhi3; Zhou, Da3; Liu, Xiao-Lin3; Yang, Rui-Xu3; Pan, Qin3; Fan, Jian-Gao3; Xue, Ya-Qian2; Fan, Jian-Gao1; , |
| 刊名 | WORLD JOURNAL OF GASTROENTEROLOGY
 |
| 出版日期 | 2019 |
| 卷号 | 25期号:20页码:2450-2462 |
| 关键词 | Gut microbiota Trimethylamine N-oxide Nonalcoholic steatohepatitis Endoplasmic reticulum stress Cholesterol |
| ISSN号 | 1007-9327 |
| DOI | 10.3748/wjg.v25.i20.2450 |
| 文献子类 | Article |
| 英文摘要 | BACKGROUND Trimethylamine N-oxide (TMAO) has been shown to be involved in cardiovascular disease (CVD). However, its role in nonalcoholic steatohepatitis (NASH) is unknown. AIM To determine the effect of TMAO on the progression of NASH. METHODS A rat model was induced by 16-wk high-fat high-cholesterol (HFHC) diet feeding and TMAO was administrated by daily oral gavage for 8 wk. RESULTS Oral TMAO intervention attenuated HFHC diet-induced steatohepatitis in rats. Histological evaluation showed that TMAO treatment significantly alleviated lobular inflammation and hepatocyte ballooning in the livers of rats fed a HFHC diet. Serum levels of alanine aminotransferase and aspartate aminotransferase were also decreased by TMAO treatment. Moreover, hepatic endoplasmic reticulum (ER) stress and cell death were mitigated in HFHC diet-fed TMAO-treated rats. Hepatic and serum levels of cholesterol were both decreased by TMAO treatment in rats fed a HFHC diet. Furthermore, the expression levels of intestinal cholesterol transporters were detected. Interestingly, cholesterol influx-related Niemann-Pick C1-like 1 was downregulated and cholesterol efflux-related ABCG5/8 were upregulated by TMAO treatment in the small intestine. Gut microbiota analysis showed that TMAO could alter the gut microbial profile and restore the diversity of gut flora. CONCLUSION These data suggest that TMAO may modulate the gut microbiota, inhibit intestinal cholesterol absorption, and ameliorate hepatic ER stress and cell death under cholesterol overload, thereby attenuating HFHC diet-induced steatohepatitis in rats. Further studies are needed to evaluate the influence on CVD and define the safe does of TMAO treatment. |
| 学科主题 | Gastroenterology & Hepatology |
| WOS关键词 | ENDOPLASMIC-RETICULUM STRESS ; LOW-CALORIE DIET ; GUT MICROBIOTA ; LIVER-DISEASE ; BILE-ACID ; METABOLISM ; OBESITY ; PHOSPHATIDYLCHOLINE ; PATHOGENESIS |
| 语种 | 英语 |
| WOS记录号 | WOS:000469214800005 |
| 出版者 | BAISHIDENG PUBLISHING GROUP INC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/573]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Key Lab Pediat Gastroenterol & Nutr, Shanghai 200092, Peoples R China, 2.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Key Lab Nutr Metab & Food Safety,Shanghai Ins, Shanghai 200031, Peoples R China; 3.Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Gastroenterol, Ctr Fatty Liver,Sch Med, Shanghai 200092, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhao, Ze-Hua,Xin, Feng-Zhi,Zhou, Da,et al. Trimethylamine N-oxide attenuates high-fat high-cholesterol diet-induced steatohepatitis by reducing hepatic cholesterol overload in rats[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2019,25(20):2450-2462. |
| APA | Zhao, Ze-Hua.,Xin, Feng-Zhi.,Zhou, Da.,Liu, Xiao-Lin.,Yang, Rui-Xu.,...&,.(2019).Trimethylamine N-oxide attenuates high-fat high-cholesterol diet-induced steatohepatitis by reducing hepatic cholesterol overload in rats.WORLD JOURNAL OF GASTROENTEROLOGY,25(20),2450-2462. |
| MLA | Zhao, Ze-Hua,et al."Trimethylamine N-oxide attenuates high-fat high-cholesterol diet-induced steatohepatitis by reducing hepatic cholesterol overload in rats".WORLD JOURNAL OF GASTROENTEROLOGY 25.20(2019):2450-2462. |
入库方式： OAI收割
来源：上海营养与健康研究所
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