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Peli1 controls the survival of dopaminergic neurons through modulating microglia-mediated neuroinflammation

文献类型：期刊论文

作者Dai, Dongfang2,3; Mao, Chaoming2,3; Xiao, Yichuan1,2,3; Yuan, Jia1; Wang, Yan1; Xu, Jing1; ,
刊名SCIENTIFIC REPORTS
出版日期2019
卷号9期号:-页码:8034
ISSN号2045-2322
DOI10.1038/s41598-019-44573-w
文献子类Article
英文摘要Chronic neuroinflammation is known to contributes to the toxicity of neurodegeneration of Parkinson's disease (PD). However, the molecular and cellular mechanisms controlling inflammatory responses in the central nervous system remain poorly understood. Here we found that a E3 ubiquitin ligase Peli1 is dramatically induced only in the substantia nigra (SN) of the human and mouse PD brains. The ablation of Peli1 significantly suppressed LPS-induced production of neurotoxic mediators and proinflammatory cytokines in SN and in primary microglia, whereas Peli1 is dispensable for the inflammatory responses in astrocyte. Accordingly, Peli1 deficiency markedly inhibited neuron death induced by the conditioned medium from LPS-stimulated microglia. Mechanistical study suggested that Peli1 acts as a positive regulator of inflammatory response in microglia through activation of NF-kappa B and MAP kinase. Our results established Peli1 as a critical mediator in the regulation of microglial activation and neuroinflammation-induced death of dopaminergic neurons during PD pathogenesis, suggesting that targeting Peli1 may have therapeutic effect in neuroinflammation.
学科主题Science & Technology - Other Topics
WOS关键词GROWTH-FACTOR-ALPHA ; PARKINSONS-DISEASE ; SUBSTANTIA-NIGRA ; INNATE IMMUNITY ; INFLAMMATION ; ACTIVATION ; NEURODEGENERATION ; BRAIN ; TLR ; ASTROCYTES
语种英语
WOS记录号WOS:000469318900003
出版者NATURE PUBLISHING GROUP
版本出版稿
源URL[http://202.127.25.144/handle/331004/575]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Univ Chinese Acad Sci, Chinese Acad Sci, CAS Key Lab Tissue Microenvironm & Tumor, Shanghai Inst Nutr & Hlth,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China,
2.Jiangsu Univ, Affiliated Hosp, Dept Nucl Med, Zhenjiang 212001, Jiangsu, Peoples R China;
3.Jiangsu Univ, Affiliated Hosp, Inst Oncol, Zhenjiang 212001, Jiangsu, Peoples R China;
推荐引用方式
GB/T 7714		 Dai, Dongfang,Mao, Chaoming,Xiao, Yichuan,et al. Peli1 controls the survival of dopaminergic neurons through modulating microglia-mediated neuroinflammation[J]. SCIENTIFIC REPORTS,2019,9(-):8034.
APA Dai, Dongfang.,Mao, Chaoming.,Xiao, Yichuan.,Yuan, Jia.,Wang, Yan.,...&,.(2019).Peli1 controls the survival of dopaminergic neurons through modulating microglia-mediated neuroinflammation.SCIENTIFIC REPORTS,9(-),8034.
MLA Dai, Dongfang,et al."Peli1 controls the survival of dopaminergic neurons through modulating microglia-mediated neuroinflammation".SCIENTIFIC REPORTS 9.-(2019):8034.

入库方式： OAI收割

来源：上海营养与健康研究所

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