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Cancer and Microenvironment Plasticity: Double-Edged Swords in Metastasis

文献类型：期刊论文

作者Zhuang, Xueqian1,2; Zhang, Hao1; Hu, Guohong1; ,
刊名TRENDS IN PHARMACOLOGICAL SCIENCES
出版日期2019
卷号40期号:6页码:419-429
ISSN号0165-6147
DOI10.1016/j.tips.2019.04.005
文献子类Review
英文摘要Cancer initiates at one site (primary tumor) and, in most cases, spreads to other distant organs (metastasis). During the multistep process of metastasis, primary tumor cells acquire cellular and phenotypic plasticity to survive and thrive in different environments. Moreover, cancer cells also utilize and educate microenvironmental components by reshaping them into accomplices of metastasis. Recent studies have identified a plethora of new molecular and cellular modulators of metastasis that have dynamic or even opposite roles, dominating the phenotypic plasticity of both tumoral and microenvironmental components. In this review we discuss their bipotential functions and the possible underpinning mechanisms, as well as their implications for targeted cancer therapy.
学科主题Pharmacology & Pharmacy
WOS关键词BREAST-CANCER ; TGF-BETA ; TUMOR MICROENVIRONMENT ; EARLY DISSEMINATION ; CELL-PROLIFERATION ; INHIBITOR ; NEUTROPHILS ; LUNG ; PROGRESSION ; ACTIVATION
语种英语
WOS记录号WOS:000469437500008
出版者ELSEVIER SCIENCE LONDON
版本出版稿
源URL[http://202.127.25.144/handle/331004/578]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Chinese Acad Sci, CAS Key Lab Tissue Microenvironm & Tumor, Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China;
2.Mem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, New York, NY 10065 USA,
推荐引用方式
GB/T 7714		 Zhuang, Xueqian,Zhang, Hao,Hu, Guohong,et al. Cancer and Microenvironment Plasticity: Double-Edged Swords in Metastasis[J]. TRENDS IN PHARMACOLOGICAL SCIENCES,2019,40(6):419-429.
APA Zhuang, Xueqian,Zhang, Hao,Hu, Guohong,&,.(2019).Cancer and Microenvironment Plasticity: Double-Edged Swords in Metastasis.TRENDS IN PHARMACOLOGICAL SCIENCES,40(6),419-429.
MLA Zhuang, Xueqian,et al."Cancer and Microenvironment Plasticity: Double-Edged Swords in Metastasis".TRENDS IN PHARMACOLOGICAL SCIENCES 40.6(2019):419-429.

入库方式： OAI收割

来源：上海营养与健康研究所

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