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PrecursorFinder: a customized biosynthetic precursor explorer

文献类型：期刊论文

作者Yuan, Le1,4,5; Tian, Yu4,5; Ding, Shaozhen1; Liu, Yanfang4,5; Chen, Fu3,4; Zhang, Tong3,4; Tu, WZ (Tu, Weizhong2; Chen, Junni2; Hu, Qian-Nan1
刊名BIOINFORMATICS
出版日期2019
卷号35期号:9页码:1603-1604
关键词mineralocorticoid receptor endothelial cells angiogenesis STAT3
ISSN号1367-4803
DOI10.1093/bioinformatics/bty838
文献子类Article
英文摘要Synthetic biology has a great potential to produce high value pharmaceuticals, commodities or bulk chemicals. However, many biosynthetic target molecules have no defined or predicted biosynthetic pathways. Biosynthetic precursors are crucial to create biosynthetic pathways. Thus computer-assisted tools for precursor identification are urgently needed to develop novel metabolic pathways. To this end, we present PrecursorFinder, a computational tool that explores biosynthetic precursors for the query target molecules using chemical structure, similarity as well as MCS (maximum common substructure). This platform comprises more than 60 000 compounds biosynthesized for being promising precursors, which are extracted from >500 000 scientific literatures and manually curated by more than 100 people over the past 8years. The PrecursorFinder could speed up the process of biosynthesis research and make synthetic biology or metabolic engineering more efficient. Availability and implementation PrecursorFinder is available at: http://www.rxnfinder.org/precursorfinder/. Supplementary information Supplementary data are available at Bioinformatics online.
学科主题Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Computer Science ; Mathematical & Computational Biology ; Mathematics
WOS关键词PATHWAYS
语种英语
WOS记录号WOS:000469491000028
出版者OXFORD UNIV PRESS
版本出版稿
源URL[http://202.127.25.144/handle/331004/582]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.‎Univ Chinese Acad Sci, Chinese Acad Sci, CAS Key Lab Computat Biol,CAS MPG Partner Inst Co, Shanghai Inst Nutr & Hlth,Shanghai Inst Biol Sci, Shanghai 200333, Peoples R China;
2.Wuhan LifeSynther Sci & Technol Co Ltd, Wuhan 430070, Peoples R China
3.Tianjin Univ Sci & Technol, Coll Biotechnol, Tianjin 300457, Peoples R China;
4.‎Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Tianjin 300308, Peoples R China;
5.Univ Chinese Acad Sci, Beijing 100864, Peoples R China;
推荐引用方式
GB/T 7714		 Yuan, Le,Tian, Yu,Ding, Shaozhen,et al. PrecursorFinder: a customized biosynthetic precursor explorer[J]. BIOINFORMATICS,2019,35(9):1603-1604.
APA Yuan, Le.,Tian, Yu.,Ding, Shaozhen.,Liu, Yanfang.,Chen, Fu.,...&Hu, Qian-Nan.(2019).PrecursorFinder: a customized biosynthetic precursor explorer.BIOINFORMATICS,35(9),1603-1604.
MLA Yuan, Le,et al."PrecursorFinder: a customized biosynthetic precursor explorer".BIOINFORMATICS 35.9(2019):1603-1604.

入库方式： OAI收割

来源：上海营养与健康研究所

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