Elevated sodium chloride drives type I interferon signaling in macrophages and increases antiviral resistance
文献类型：期刊论文
| 作者 | Zhang, Wu-Chang1,4; Du, Lin-Juan1,4; Zheng, Xiao-Jun1,4,5; Shi, Chaoji1,4; Chen, Bo-Yan1,4; Sun, Xue-Nan1,4,5; Li, Chao1,4,5; Zhang, Yu-Yao1,4,5; Liu, Yan1,4; Jiang, Xinquan1,4 |
| 刊名 | JOURNAL OF BIOLOGICAL CHEMISTRY
 |
| 出版日期 | 2018 |
| 卷号 | 293期号:3页码:1030-1039 |
| 关键词 | aging antagonistic pleiotropy evolution gene expression genetic drift mutation accumulation protein sequence conservation |
| ISSN号 | 0021-9258 |
| DOI | 10.1074/jbc.M117.805093 |
| 文献子类 | Article |
| 英文摘要 | Type I IFN production and signaling in macrophages play critical roles in innate immune responses. High salt (i.e. high concentrations of NaCl) has been proposed to be an important environmental factor that influences immune responses in multiple ways. However, it remains unknown whether high salt regulates type I IFN production and signaling in macrophages. Here, we demonstrated that high salt promoted IFN beta production and its signaling in both human and mouse macrophages, and consequentially primed macrophages for strengthened immune sensing and signaling when challenged with viruses or viral nucleic acid analogues. Using both pharmacological inhibitors and RNA interference we showed that these effects of high salt on IFN beta signaling were mediated by the p38 MAPK/ATF2/AP1 signaling pathway. Consistently, high salt increased resistance to vesicle stomatitis virus (VSV) infection in vitro. In vivo data indicated that a high-salt diet protected mice from lethal VSV infection. Taken together, these results identify high salt as a crucial regulator of type I IFN production and signaling, shedding important new light on the regulation of innate immune responses. |
| 学科主题 | Biochemistry & Molecular Biology |
| WOS关键词 | PATHOGENIC T(H)17 CELLS ; REGULATORY T-CELLS ; VACCINE ADJUVANT ; VIRUS-INFECTION ; ACTIVATION ; INDUCTION ; PATHWAY ; HOMEOSTASIS ; DISEASE ; KINASE |
| 语种 | 英语 |
| WOS记录号 | WOS:000422864500023 |
| 出版者 | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/585]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Natl Clin Res Ctr Stomatol, Shanghai Res Inst Stomatol, Shanghai 200011, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Pasteur Shanghai, Shanghai 200031, Peoples R China, 3.Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Sch Med, Shanghai 200030, Peoples R China; 4.Shanghai Jiao Tong Univ, Sch Stomatol, Ninth Peoples Hosp, Sch Med, Shanghai 200011, Peoples R China; 5.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Wu-Chang,Du, Lin-Juan,Zheng, Xiao-Jun,et al. Elevated sodium chloride drives type I interferon signaling in macrophages and increases antiviral resistance[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2018,293(3):1030-1039. |
| APA | Zhang, Wu-Chang.,Du, Lin-Juan.,Zheng, Xiao-Jun.,Shi, Chaoji.,Chen, Bo-Yan.,...&,.(2018).Elevated sodium chloride drives type I interferon signaling in macrophages and increases antiviral resistance.JOURNAL OF BIOLOGICAL CHEMISTRY,293(3),1030-1039. |
| MLA | Zhang, Wu-Chang,et al."Elevated sodium chloride drives type I interferon signaling in macrophages and increases antiviral resistance".JOURNAL OF BIOLOGICAL CHEMISTRY 293.3(2018):1030-1039. |
入库方式： OAI收割
来源：上海营养与健康研究所
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