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Geniposide Improves Glucose Homeostasis via Regulating FoxO1/PDK4 in Skeletal Muscle

文献类型：期刊论文

作者Li, Yan2,3,4; Wang, Li2,3; Pan, Haiou3; Zhang, Hui3; Qian, Haifeng3; Wang, Hui4; Liu, Shengnan4; Ying, Hao4; Zhang, Xuetong1; ,
刊名JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
出版日期2019
卷号67期号:16页码:4483-4492
ISSN号0021-8561
关键词geniposide skeletal muscle glucose utilization PDK4 FoxO1
DOI10.1021/acs.jafc.9b00402
文献子类Article
英文摘要It is well-known that imbalance state of glucose metabolism triggers many metabolic diseases and glucose uptake in skeletal muscle accounts for 90% of body weight. Geniposide is one of the major natural bioactive constituents of gardenia fruit, and the regulation of geniposide on glucose metabolism in skeletal muscle has not yet been investigated. Here, on the basis of microarray analysis, we discovered that geinposide decreased pyruvate dehydrogenase kinase 4 (PDK4) expression in skeletal muscle of mice and subsequently found that geniposide inhibited the expressions of forkhead box O1 (FoxO1), PDK4, and phosphorylated pyruvate dehydrogenase in vitro and in vivo. Moreover, geniposide promoted a switch of slow-to-fast myofiber type and glucose utilization, suggesting that geniposide improved glucose homeostasis. In addition, mechanistic studies revealed that geniposide played above roles by regulating FoxO1/PDK4, which controlled fuel selection via pyruvate dehydrogenase. Meanwhile, effects of geniposide mentioned above could be reversed by FoxO1 overexpression. Together, these results establish that geniposide confers controls on fuel usage and glucose homeostasis through FoxO1/PDK4 in skeletal muscle.
学科主题Agriculture ; Chemistry ; Food Science & Technology
WOS关键词METABOLIC FLEXIBILITY ; GASTROCNEMIUS-MUSCLE ; SLOW-TWITCH ; PHOSPHORYLATION ; DYSFUNCTION ; EXPRESSION ; EXERCISE ; PROTEIN ; OBESITY ; MICE
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:000466052700010
版本出版稿
源URL[http://202.127.25.144/handle/331004/592]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Jiangnan Univ, Wuxi Peoples Hosp 4, Affiliated Hosp, Wuxi 214062, Jiangsu, Peoples R China,
2.Jiangnan Univ, Sch Food Sci & Technol, Jiangsu Key Lab Adv Food Mfg Equipment & Technol, 1800 Lihu Ave, Wuxi 214122, Jiangsu, Peoples R China;
3.Jiangnan Univ, Sch Food Sci & Technol, State Key Lab Food Sci & Technol, 1800 Lihu Ave, Wuxi 214122, Jiangsu, Peoples R China;
4.Univ Chinese Acad Sci, CAS, Shanghai Inst Biol Sci, Key Lab Nutr Metab & Food Safety, 320 Yueyang Rd, Shanghai 200031, Peoples R China;
推荐引用方式
GB/T 7714		 Li, Yan,Wang, Li,Pan, Haiou,et al. Geniposide Improves Glucose Homeostasis via Regulating FoxO1/PDK4 in Skeletal Muscle[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2019,67(16):4483-4492.
APA Li, Yan.,Wang, Li.,Pan, Haiou.,Zhang, Hui.,Qian, Haifeng.,...&,.(2019).Geniposide Improves Glucose Homeostasis via Regulating FoxO1/PDK4 in Skeletal Muscle.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,67(16),4483-4492.
MLA Li, Yan,et al."Geniposide Improves Glucose Homeostasis via Regulating FoxO1/PDK4 in Skeletal Muscle".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 67.16(2019):4483-4492.

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来源：上海营养与健康研究所

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