A positive role for polycomb in transcriptional regulation via H4K20me1 (vol 27, pg 594, 2017)
文献类型：期刊论文
| 作者 | Lv, Xiangdong6; Chen, Hao6; Yang, Bo6; Yang, Xiaofeng6; Xia, Yuanxin6; Pan, Chenyu6; Fu, Lin6; Zhang, Shuo6; Han, Hui6; Zhou, Zhaocai6 |
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2017 |
| 卷号 | 27期号:4页码:594-594 |
| ISSN号 | 1001-0602 |
| DOI | 10.1038/cr.2017.50 |
| 文献子类 | Correction |
| 英文摘要 | Characterizing the stem cells responsible for lung repair and regeneration is important for the treatment of pulmonary diseases. Recently, a unique cell population located at the bronchioalveolar-duct junctions has been proposed to comprise endogenous stem cells for lung regeneration. However, the role of bronchioalveolar stem cells (BASCs) in vivo remains debated, and the contribution of such cells to lung regeneration is not known. Here we generated a genetic lineage-tracing system that uses dual recombinases (Cre and Dre) to specifically track BASCs in vivo. Fate-mapping and clonal analysis showed that BASCs became activated and responded distinctly to different lung injuries, and differentiated into multiple cell lineages including club cells, ciliated cells, and alveolar type 1 and type 2 cells for lung regeneration. This study provides in vivo genetic evidence that BASCs are bona fide lung epithelial stem cells with deployment of multipotency and self-renewal during lung repair and regeneration. |
| 学科主题 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000398770500015 |
| 出版者 | INST BIOCHEMISTRY & CELL BIOLOGY |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/593]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Computat Biol, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Shanghai 200031, Peoples R China; 2.Wuhan Univ, Key Lab Intestinal & Colorectal Dis, Wuhan 430072, Hubei, Peoples R China; 3.Wuhan Univ, Dept Biochem & Mol Biol, Coll Life Sci, Wuhan 430072, Hubei, Peoples R China; 4.Chinese Acad Sci, State Key Lab Mol Biol, CAS Ctr Excellence Mol Cell Sci,Shanghai Inst Bio, Innovat Ctr Cell Signaling Network Inst Biochem &, Shanghai 200031, Peoples R China; 5.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China, 6.Chinese Acad Sci, State Key Lab Cell Biol, CAS Ctr Excellence Mol Cell Sci,Innovat Ctr Cell, Innovat Ctr Cell Signaling Network,Shanghai Inst, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Lv, Xiangdong,Chen, Hao,Yang, Bo,et al. A positive role for polycomb in transcriptional regulation via H4K20me1 (vol 27, pg 594, 2017)[J]. CELL RESEARCH,2017,27(4):594-594. |
| APA | Lv, Xiangdong.,Chen, Hao.,Yang, Bo.,Yang, Xiaofeng.,Xia, Yuanxin.,...&,.(2017).A positive role for polycomb in transcriptional regulation via H4K20me1 (vol 27, pg 594, 2017).CELL RESEARCH,27(4),594-594. |
| MLA | Lv, Xiangdong,et al."A positive role for polycomb in transcriptional regulation via H4K20me1 (vol 27, pg 594, 2017)".CELL RESEARCH 27.4(2017):594-594. |
入库方式： OAI收割
来源：上海营养与健康研究所
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