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Associations of Monounsaturated Fatty Acids From Plant and Animal Sources With Total and Cause-Specific Mortality in Two US Prospective Cohort Studies

文献类型：期刊论文

作者Guasch-Ferre, Marta1,4,6; Zong, Geng4; Willett, Walter C.1,4,6; Hu, Frank B.1,4,5,6; Sun, Qi1,4,6; Willett, Walter C.5; Zong, Geng3; Zock, Peter L.2; Wanders, Anne J.2; ,
刊名CIRCULATION RESEARCH
出版日期2019
卷号124期号:8页码:1266-1275
关键词carbohydrates cardiovascular disease chronic disease diet fatty acids
ISSN号0009-7330
DOI10.1161/CIRCRESAHA.118.313996
文献子类Article
英文摘要Rationale: Dietary monounsaturated fatty acids (MUFAs) can come from both plant and animal sources with divergent nutrient profiles that may potentially obscure the associations of total MUFAs with chronic diseases. Objective: To investigate the associations of cis-MUFA intake from plant (MUFA-P) and animal (MUFA-A) sources with total and cause-specific mortality. Methods and Results: We followed 63 412 women from the NHS (Nurses' Health Study; 1990-2012) and 29 966 men from the HPFS (Health Professionals Follow-Up Study; 1990-2012). MUFA-Ps and MUFA-As were calculated based on data collected through validated food frequency questionnaires administered every 4 years and updated food composition databases. During 1 896 864 person-years of follow-up, 20 672 deaths occurred. Total MUFAs and MUFA-Ps were inversely associated with total mortality after adjusting for potential confounders, whereas MUFA-As were associated with higher mortality. When MUFA-Ps were modeled to isocalorically replace other macronutrients, hazard ratios (HRs, 95% CIs) of total mortality were 0.84 (0.77-0.92; P<0.001) for replacing saturated fatty acids, 5% of energy); 0.86 (0.82-0.91; P<0.001) for replacing refined carbohydrates (5% energy); 0.91 (0.85-0.97; P<0.001) for replacing trans fats (2% energy), and 0.77 (0.71-0.82; P<0.001) for replacing MUFA-As (5% energy). For isocalorically replacing MUFA-As with MUFA-Ps, HRs (95% CIs) were 0.74 (0.64-0.86; P<0.001) for cardiovascular mortality; 0.73 (0.65-0.82; P<0.001) for cancer mortality, and 0.82 (0.73-0.91; P<0.001) for mortality because of other causes. Conclusions: Higher intake of MUFA-Ps was associated with lower total mortality, and MUFA-As intake was associated with higher mortality. Significantly lower mortality risk was observed when saturated fatty acids, refined carbohydrates, or trans fats were replaced by MUFA-Ps, but not MUFA-As. These data suggest that other constituents in animal foods, such as saturated fatty acids, may confound the associations for MUFAs when they are primarily derived from animal products. More evidence is needed to elucidate the differential associations of MUFAPs and MUFA-As with mortality.
学科主题Cardiovascular System & Cardiology ; Hematology
WOS关键词CORONARY-HEART-DISEASE ; ALL-CAUSE MORTALITY ; RED MEAT CONSUMPTION ; CARDIOVASCULAR-DISEASE ; NUT CONSUMPTION ; RISK-FACTORS ; CANCER-RISK ; DIETARY-FAT ; QUESTIONNAIRE ; METAANALYSIS
语种英语
WOS记录号WOS:000469343500023
出版者LIPPINCOTT WILLIAMS & WILKINS
版本出版稿
源URL[http://202.127.25.144/handle/331004/594]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA;
2.Unilever Res Labs, Vlaardingen, Netherlands,
3.Univ Chinese Acad Sci, CAS Key Lab Nutr Metab & Food Safety, Inst Nutr & Hlth, Shanghai Inst Biol Sci, Beijing, Peoples R China;
4.Harvard TH Chan Sch Publ Hlth, Dept Nutr, 665 Huntington Ave, Boston, MA 02115 USA;
5.Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA;
6.Harvard Med Sch, Boston, MA 02115 USA;
推荐引用方式
GB/T 7714		 Guasch-Ferre, Marta,Zong, Geng,Willett, Walter C.,et al. Associations of Monounsaturated Fatty Acids From Plant and Animal Sources With Total and Cause-Specific Mortality in Two US Prospective Cohort Studies[J]. CIRCULATION RESEARCH,2019,124(8):1266-1275.
APA Guasch-Ferre, Marta.,Zong, Geng.,Willett, Walter C..,Hu, Frank B..,Sun, Qi.,...&,.(2019).Associations of Monounsaturated Fatty Acids From Plant and Animal Sources With Total and Cause-Specific Mortality in Two US Prospective Cohort Studies.CIRCULATION RESEARCH,124(8),1266-1275.
MLA Guasch-Ferre, Marta,et al."Associations of Monounsaturated Fatty Acids From Plant and Animal Sources With Total and Cause-Specific Mortality in Two US Prospective Cohort Studies".CIRCULATION RESEARCH 124.8(2019):1266-1275.

入库方式： OAI收割

来源：上海营养与健康研究所

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