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Leukocyte Cytoskeleton Polarization Is Initiated by Plasma Membrane Curvature from Cell Attachment

文献类型：期刊论文

作者Ren, Chunguang16; Yuan, Qianying16; Tang, Wenwen16; Wu, Dianqing16; Braun, Martha1,2,15; Karatekin, Erdem1,2,15; Zhang, Xia3; Petri, Bjorn4,6; Kubes, Paul4; Zhang, Jiasheng7
刊名DEVELOPMENTAL CELL
出版日期2019
卷号49期号:2页码:206-+
ISSN号1534-5807
DOI10.1016/j.devcel.2019.02.023
文献子类Article
英文摘要Cell polarization is important for various biological processes. However, its regulation, particularly initiation, is incompletely understood. Here, we investigated mechanisms by which neutrophils break their symmetry and initiate their cytoskeleton polarization from an apolar state in circulation for their extravasation during inflammation. We show here that a local increase in plasma membrane (PM) curvature resulting from cell contact to a surface triggers the initial breakage of the symmetry of an apolar neutrophil and is required for subsequent polarization events induced by chemical stimulation. This local increase in PM curvature recruits SRGAP2 via its F-BAR domain, which in turn activates PI4KA and results in PM PtdIns4P polarization. Polarized PM PtdIns4P is targeted by RPH3A, which directs PIP5K1C90 and subsequent phosphorylated myosin light chain polarization, and this polarization signaling axis regulates neutrophil firm attachment to endothelium. Thus, this study reveals a mechanism for the initiation of cell cytoskeleton polarization.
学科主题Cell Biology ; Developmental Biology
WOS关键词NEUTROPHIL POLARIZATION ; PHOSPHATIDYLINOSITOL 4-PHOSPHATE ; RHOA ACTIVITY ; BAR DOMAIN ; IN-VIVO ; MIGRATION ; POLARITY ; ADHESION ; SIGNALS ; SRGAP2
语种英语
出版者CELL PRESS
WOS记录号WOS:000465117900006
版本出版稿
源URL[http://202.127.25.144/handle/331004/597]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Yale Univ, Dept Cellular & Mol Physiol, New Haven, CT 06520 USA;
2.Yale Univ, Nanobiol Inst, New Haven, CT 06520 USA;
3.Zhejiang Univ, Affiliated Hosp 1, Dept Geriatr, Coll Med, Hangzhou, Zhejiang, Peoples R China;
4.Univ Calgary, Snyder Inst Chron Dis Mouse Phen Resource Lab, Calgary, AB T2N 4N1, Canada;
5.CNRS, Paris, France,
6.Univ Calgary, Dept Microbiol Immunol & Infect Dis, Calgary, AB T2N 4N1, Canada;
7.Yale Univ, Dept Internal Med, New Haven, CT 06520 USA;
8.Yale Univ, Dept Biomed Engn, New Haven, CT 06520 USA;
9.Bar Ilan Univ, Mina & Everard Goodman Fac Life Sci, IL-5290002 Ramat Gan, Israel;
10.Univ Chinese Acad Sci, Chinese Acad Sci CAS, Shanghai Inst Biol Sci, Shanghai Inst Nutr & Hlth, Shanghai, Peoples R China;
推荐引用方式
GB/T 7714		 Ren, Chunguang,Yuan, Qianying,Tang, Wenwen,et al. Leukocyte Cytoskeleton Polarization Is Initiated by Plasma Membrane Curvature from Cell Attachment[J]. DEVELOPMENTAL CELL,2019,49(2):206-+.
APA Ren, Chunguang.,Yuan, Qianying.,Tang, Wenwen.,Wu, Dianqing.,Braun, Martha.,...&,.(2019).Leukocyte Cytoskeleton Polarization Is Initiated by Plasma Membrane Curvature from Cell Attachment.DEVELOPMENTAL CELL,49(2),206-+.
MLA Ren, Chunguang,et al."Leukocyte Cytoskeleton Polarization Is Initiated by Plasma Membrane Curvature from Cell Attachment".DEVELOPMENTAL CELL 49.2(2019):206-+.

入库方式： OAI收割

来源：上海营养与健康研究所

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