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Competitive endogenous RNA is an intrinsic component of EMT regulatory circuits and modulates EMT

文献类型：期刊论文

作者Liu, Yuwei2,3; Xue, Mengzhu2; Du, Shaowei2; Liu, Haiyue2,3; Jia, Guoyi2,4; Wang, Peng1,2,3,5,9; Zhang, Liwen3; Du, Shaowei4; Feng, Wanwan5; Zhang, Ke5
刊名NATURE COMMUNICATIONS
出版日期2019
卷号10期号:-页码:1637
ISSN号2041-1723
DOI10.1038/s41467-019-09649-1
文献子类Article
英文摘要The competitive endogenous RNA (ceRNA) hypothesis suggests an intrinsic mechanism to regulate biological processes. However, whether the dynamic changes of ceRNAs can modulate miRNA activities remains controversial. Here, we examine the dynamics of ceRNAs during TGF-beta-induced epithelial-to-mesenchymal transition (EMT). We observe that TGFBI, a transcript highly induced during EMT in A549 cells, acts as the ceRNA for miR-21 to modulate EMT. We further identify FN1 as the ceRNA for miR-200c in the canonical SNAIL-ZEB-miR200 circuit in MCF10A cells. Experimental assays and computational simulations demonstrate that the dynamically induced ceRNAs are directly coupled with the canonical double negative feedback loops and are critical to the induction of EMT. These results help to establish the relevance of ceRNA in cancer EMT and suggest that ceRNA is an intrinsic component of the EMT regulatory circuit and may represent a potential target to disrupt EMT during tumorigenesis.
学科主题Science & Technology - Other Topics
WOS关键词EPITHELIAL-MESENCHYMAL TRANSITION ; TGF-BETA ; CERNA HYPOTHESIS ; MIR-200 FAMILY ; UP-REGULATION ; MICRORNA ; CANCER ; PROMOTES ; TRANSCRIPTION ; EXPRESSION
语种英语
WOS记录号WOS:000463872400013
出版者NATURE PUBLISHING GROUP
版本出版稿
源URL[http://202.127.25.144/handle/331004/598]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Fudan Univ, Precis Canc Med Ctr, Shanghai Canc Ctr, Shanghai 200032, Peoples R China;
2.Chinese Acad Sci, Shanghai Adv Res Inst, Lab Syst Biol, Shanghai 200031, Peoples R China;
3.Univ Chinese Acad Sci, Shanghai 200031, Peoples R China;
4.Shanghai Univ, Sch Life Sci, Shanghai 200031, Peoples R China;
5.Chinese Acad Sci, Biomed Big Data Ctr, CAS Key Lab Computat Biol,Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol,Shanghai Inst, Shanghai 200031, Peoples R China;
6.Chinese Acad Sci, Key Lab Syst Biol, Ctr Excellence Mol Cell Sci, Inst Biochem & Cell Biol,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China;
7.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China;
8.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China;
9.Fudan Univ, Shanghai Canc Ctr, Dept Breast Surg, Key Lab Breast Canc Shanghai, Shanghai 200032, Peoples R China;
10.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China;
推荐引用方式
GB/T 7714		 Liu, Yuwei,Xue, Mengzhu,Du, Shaowei,et al. Competitive endogenous RNA is an intrinsic component of EMT regulatory circuits and modulates EMT[J]. NATURE COMMUNICATIONS,2019,10(-):1637.
APA Liu, Yuwei.,Xue, Mengzhu.,Du, Shaowei.,Liu, Haiyue.,Jia, Guoyi.,...&,.(2019).Competitive endogenous RNA is an intrinsic component of EMT regulatory circuits and modulates EMT.NATURE COMMUNICATIONS,10(-),1637.
MLA Liu, Yuwei,et al."Competitive endogenous RNA is an intrinsic component of EMT regulatory circuits and modulates EMT".NATURE COMMUNICATIONS 10.-(2019):1637.

入库方式： OAI收割

来源：上海营养与健康研究所

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