Rapid evolution of a retro-transposable hotspot of ovine genome underlies the alteration of BMP2 expression and development of fat tails
文献类型：期刊论文
| 作者 | Pan, Zhangyuan1,3; Liu, Qiuyue3; Zhou, Zhengkui3; Di, Ran3; An, Xuejiao3; Wang, Xiangyu3; Hu, Wenping3; Guo, Xiaofei3; Chu, Mingxing3; Li, Shengdi2,4 |
| 刊名 | BMC GENOMICS
 |
| 出版日期 | 2019 |
| 卷号 | 20期号:-页码:261 |
| 关键词 | Retro-transposable hotspot BMP2 Fat tail Sheep Evolution |
| ISSN号 | 1471-2164 |
| DOI | 10.1186/s12864-019-5620-6 |
| 文献子类 | Article |
| 英文摘要 | BackgroundSheep have developed the ability to store fat in their tails, which is a unique way of reserving energy to survive a harsh environment. However, the mechanism underlying this adaptive trait remains largely unsolved.ResultsIn the present study, we provide evidence for the genetic determinants of fat tails, based on whole genome sequences of 89 individual sheep. A genome-wide scan of selective sweep identified several candidate loci including a region at chromosome 13, a haplotype of which underwent rapid evolution and spread through fat-tailed populations in China and the Middle East. Sequence analysis revealed an inter-genic origin of this locus, which later became a hotspot of ruminant-specific retro-transposon named BovB. Additionally, the candidate locus was validated based on a fat- and thin-tailed cross population. The expression of an upstream gene BMP2 was differentially regulated between fat-tailed and thin-tailed individuals in tail adipose and several other tissue types.ConclusionsOur findings suggest the fixation of fat tails in domestic sheep is caused by a selective sweep near a retro-transposable hotspot at chromosome 13, the diversity of which specifically affects the expression of BMP2. The present study has shed light onto the understanding of fat metabolism. |
| 学科主题 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| WOS关键词 | SIGNALING PATHWAY ; STEM-CELLS ; BODY-FAT ; SHEEP ; SELECTION ; DNA ; ASSOCIATION ; PERFORMANCE ; SIGNATURES ; ALIGNMENT |
| 语种 | 英语 |
| WOS记录号 | WOS:000463178000003 |
| 出版者 | BMC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/599]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Linyi Univ, Coll Agr & Forestry Sci, Linyi, Shandong, Peoples R China; 2.Shanghai Ind Technol Inst, Shanghai Ctr Bioinformat Technol, Shanghai, Peoples R China, 3.Chinese Acad Agr Sci, Inst Anim Sci, Beijing, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Pan, Zhangyuan,Liu, Qiuyue,Zhou, Zhengkui,et al. Rapid evolution of a retro-transposable hotspot of ovine genome underlies the alteration of BMP2 expression and development of fat tails[J]. BMC GENOMICS,2019,20(-):261. |
| APA | Pan, Zhangyuan.,Liu, Qiuyue.,Zhou, Zhengkui.,Di, Ran.,An, Xuejiao.,...&,.(2019).Rapid evolution of a retro-transposable hotspot of ovine genome underlies the alteration of BMP2 expression and development of fat tails.BMC GENOMICS,20(-),261. |
| MLA | Pan, Zhangyuan,et al."Rapid evolution of a retro-transposable hotspot of ovine genome underlies the alteration of BMP2 expression and development of fat tails".BMC GENOMICS 20.-(2019):261. |
入库方式： OAI收割
来源：上海营养与健康研究所
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