Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction
文献类型：期刊论文
| 作者 | Tang, Juan3,4; Wan, Qiangyou3; Wang, Kai3; Zhang, Jian3,4; Liu, Guizhu3; Zuo, Shengkai3; Tao, Bo3; Yu, Yu3; Yu, Ying3,4; Shen, Yujun4 |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2017 |
| 卷号 | 8期号:-页码:14656 |
| 关键词 | Spermiogenesis Histone-to-protamine exchange PHF7 Histone H2A ubiquitylation E3 ligase |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/ncomms14656 |
| 文献子类 | Article |
| 英文摘要 | Two distinct monocyte (Mo)/macrophage (Mp) subsets (Ly6C(low) and Ly6C(high)) orchestrate cardiac recovery process following myocardial infarction (MI). Prostaglandin (PG) E-2 is involved in the Mo/Mp-mediated inflammatory response, however, the role of its receptors in Mos/Mps in cardiac healing remains to be determined. Here we show that pharmacological inhibition or gene ablation of the Ep3 receptor in mice suppresses accumulation of Ly6C(low) Mos/Mps in infarcted hearts. Ep3 deletion in Mos/Mps markedly attenuates healing after MI by reducing neovascularization in peri-infarct zones. Ep3 deficiency diminishes CX3C chemokine receptor 1 (CX3CR1) expression and vascular endothelial growth factor (VEGF) secretion in Mos/Mps by suppressing TGFb1 signalling and subsequently inhibits Ly6C(low) Mos/Mps migration and angiogenesis. Targeted overexpression of Ep3 receptors in Mos/Mps improves wound healing by enhancing angiogenesis. Thus, the PGE2/Ep3 axis promotes cardiac healing after MI by activating reparative Ly6C(low) Mos/Mps, indicating that Ep3 receptor activation may be a promising therapeutic target for acute MI. |
| 学科主题 | Science & Technology - Other Topics |
| WOS关键词 | PROSTAGLANDIN E-2 SYNTHASE-1 ; MONOCYTE SUBSETS ; GENE-EXPRESSION ; CELLS IMPAIRS ; EP3 RECEPTORS ; MOUSE ; MICE ; INJURY ; SIZE ; INCREASES |
| 语种 | 英语 |
| WOS记录号 | WOS:000395972900001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/601]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Mayo Clin, Ctr Individualized Med, Div Biomed Stat & Informat, Scottsdale, AZ 85259 USA; 2.Univ Tsukuba, Int Inst Integrat Sleep Med WPI IIIS, Tsukuba, Ibaraki 3058575, Japan, 3.Univ Chinese Acad Sci, Chinese Acad Sci, Key Lab food safety Res, Inst Nutr Sci,Shanghai Inst Biol Sci,CAS Ctr Exce, Shanghai 200031, Peoples R China; 4.Tianjin Med Univ, Sch Basic Med Sci, Dept Pharmacol, Tianjin 300070, Peoples R China; 5.Univ Hong Kong, Ctr Genom Sci, LKS Fac Med, 5 Sassoon Rd, Hong Kong 999077, Hong Kong, Peoples R China; 6.Chinese Univ Hong Kong, Sch Life Sci, Hong Kong 999077, Hong Kong, Peoples R China; 7.Arizona State Univ, Dept Biomed Informat, Scottsdale, AZ 85259 USA; |
| 推荐引用方式 GB/T 7714 | Tang, Juan,Wan, Qiangyou,Wang, Kai,et al. Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction[J]. NATURE COMMUNICATIONS,2017,8(-):14656. |
| APA | Tang, Juan.,Wan, Qiangyou.,Wang, Kai.,Zhang, Jian.,Liu, Guizhu.,...&,.(2017).Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction.NATURE COMMUNICATIONS,8(-),14656. |
| MLA | Tang, Juan,et al."Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction".NATURE COMMUNICATIONS 8.-(2017):14656. |
入库方式： OAI收割
来源：上海营养与健康研究所
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