A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth
文献类型：期刊论文
| 作者 | Yang, Guang1,2,3,4,5,6; Chen, Qian1,2,3,4,5; Wen, Di1,2,3,4,5; Chen, Zhaowei1,2,3,4,5; Wang, Jinqiang1,2,3,4,5; Chen, Guojun1,2,3,4,5; Wang, Zejun1,2,3; Zhang, Xudong1,2,3,4,5; Zhang, Yuqi1,4,5; Hu, Quanyin1,4,5 |
| 刊名 | ACS NANO
 |
| 出版日期 | 2019 |
| 卷号 | 13期号:4页码:4354-4360 |
| 关键词 | drug delivery microneedle exosome keratin hair regrowth transdermal drug delivery |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.8b09573 |
| 文献子类 | Article |
| 英文摘要 | Activating hair follicle stem cells (HFSCs) to promote hair follicle regrowth holds promise for hair loss therapy, while challenges still remain to develop a scenario that enables enhanced therapeutic efficiency and easy administration. Here we describe a detachable microneedle patch-mediated drug delivery system, mainly made from hair-derived keratin, for sustained delivery of HFSC activators. It was demonstrated that this microneedle device integrated with mesenchymal stem cell (MSC)-derived exosomes and a small molecular drug, UK5099, could enhance the treatment efficiency at a reduced dosage, leading to promoted pigmentation and hair regrowth within 6 days through two rounds of administration in a mouse model. This microneedle-based transdermal drug delivery approach shows augmented efficacy compared to the subcutaneous injection of exosomes and topical administration of UK5099. |
| 学科主题 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| WOS关键词 | FOLLICULAR STEM-CELLS ; DRUG-DELIVERY ; FOLLICLES ; CYCLE ; MORPHOGENESIS ; MESENCHYME ; HYDROGEL ; DYNAMICS ; EXOSOMES ; NICHE |
| 语种 | 英语 |
| WOS记录号 | WOS:000466052900060 |
| 出版者 | AMER CHEMICAL SOC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/604]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA; 2.Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Calif NanoSyst Inst, Los Angeles, CA 90095 USA; 3.Univ Calif Los Angeles, Ctr Minimally Invas Therapeut, Los Angeles, CA 90095 USA; 4.Univ N Carolina, Joint Dept Biomed Engn, Chapel Hill, NC 27515 USA; 5.North Carolina State Univ, Raleigh, NC 27695 USA; 6.Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China; 7.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Nutr & Hlth, CAS Key Lab Tissue Microenvironm & Tumor,Shanghai, Shanghai 200031, Peoples R China; 8.Chinese Acad Sci, Inst Stem Cell & Regenerat, 1 Beichen West Rd, Beijing 100101, Peoples R China; 9.Chinese Acad Sci, Shanghai Inst Biol Sci, Changzheng Hosp Joint Ctr Translat Res, Inst Translat Res,SMMU, Shanghai 200433, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Yang, Guang,Chen, Qian,Wen, Di,et al. A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth[J]. ACS NANO,2019,13(4):4354-4360. |
| APA | Yang, Guang.,Chen, Qian.,Wen, Di.,Chen, Zhaowei.,Wang, Jinqiang.,...&,.(2019).A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth.ACS NANO,13(4),4354-4360. |
| MLA | Yang, Guang,et al."A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth".ACS NANO 13.4(2019):4354-4360. |
入库方式： OAI收割
来源：上海营养与健康研究所
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