Dynamics of Wnt activity on the acquisition of ectoderm potency in epiblast stem cells
文献类型：期刊论文
| 作者 | Osteil, Pierre7,8; Studdert, Josh B.7; Goh, Hwee Ngee7; Wilkie, Emilie E.7; Fan, Xiaochen7; Khoo, Poh-Lynn7; Salehin, Nazmus7; Knowles, Hilary7; Fossat, Nicolas7,8; Tam, Patrick P. L.7,8 |
| 刊名 | DEVELOPMENT
 |
| 出版日期 | 2019 |
| 卷号 | 146期号:7页码:UNSP dev172858 |
| ISSN号 | 0950-1991 |
| 关键词 | Epiblast stem cells Lineage propensity Wnt signalling Neurogenesis Head development |
| DOI | 10.1242/dev.172858 |
| 文献子类 | Article |
| 英文摘要 | During embryogenesis, the stringent regulation of Wnt activity is crucial for the morphogenesis of the head and brain. The loss of function of the Wnt inhibitor Dkk1 results in elevated Wnt activity, loss of ectoderm lineage attributes from the anterior epiblast, and the posteriorisation of anterior germ layer tissue towards the mesendoderm. The modulation of Wnt signalling may therefore be crucial for the allocation of epiblast cells to ectoderm progenitors during gastrulation. To test this hypothesis, we examined the lineage characteristics of epiblast stem cells (EpiSCs) that were derived and maintained under different signalling conditions. We showed that suppression of Wnt activity enhanced the ectoderm propensity of the EpiSCs. Neuroectoderm differentiation of these EpiSCs was further empowered by the robust re-activation of Wnt activity. Therefore, during gastrulation, the tuning of the signalling activities that mediate mesendoderm differentiation is instrumental for the acquisition of ectoderm potency in the epiblast. |
| 学科主题 | Developmental Biology |
| WOS关键词 | EMBRYONIC ECTODERM ; HEAD FORMATION ; AUTORADIOGRAPHIC ANALYSIS ; TRANSCRIPTION FACTOR ; MOUSE ; EXPRESSION ; GASTRULATION ; SPECIFICATION ; MORPHOGENESIS ; DICKKOPF-1 |
| 语种 | 英语 |
| 出版者 | COMPANY BIOLOGISTS LTD |
| WOS记录号 | WOS:000464583200010 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/606]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Cell Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China; 2.Univ Copenhagen, Copenhagen Hepatitis C Program CO HEP, Dept Immunol & Microbiol, Copenhagen, Denmark; 3.Hvidovre Univ Hosp, Dept Infect Dis, Hvidovre, Denmark; 4.Guangzhou Regenerat Med & Hlth GuangDong Lab GRMH, Guangzhou 510005, Guangdong, Peoples R China, 5.Univ Chinese Acad Sci, Chinese Acad Sci, CAS Key Lab Regenerat Biol, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China; 6.Chinese Acad Sci, Key Lab Computat Biol, CAS Ctr Excellence Mol Cell Sci,Shanghai Inst Bio, Collaborat Innovat Ctr Genet & Dev Biol,Max Planc, Shanghai 200031, Peoples R China; 7.Childrens Med Res Inst, Embryol Unit, Westmead, NSW 2145, Australia; 8.Univ Sydney, Fac Med & Hlth, Sch Med Sci, Sydney, NSW 2006, Australia; 9.Childrens Med Res Inst, Bioinformat Grp, Westmead, NSW 2145, Australia; |
| 推荐引用方式 GB/T 7714 | Osteil, Pierre,Studdert, Josh B.,Goh, Hwee Ngee,et al. Dynamics of Wnt activity on the acquisition of ectoderm potency in epiblast stem cells[J]. DEVELOPMENT,2019,146(7):UNSP dev172858. |
| APA | Osteil, Pierre.,Studdert, Josh B..,Goh, Hwee Ngee.,Wilkie, Emilie E..,Fan, Xiaochen.,...&,.(2019).Dynamics of Wnt activity on the acquisition of ectoderm potency in epiblast stem cells.DEVELOPMENT,146(7),UNSP dev172858. |
| MLA | Osteil, Pierre,et al."Dynamics of Wnt activity on the acquisition of ectoderm potency in epiblast stem cells".DEVELOPMENT 146.7(2019):UNSP dev172858. |
入库方式： OAI收割
来源：上海营养与健康研究所
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