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The early detection of asthma based on blood gene expression

文献类型：期刊论文

作者Wang, Shao-Bin1; Huang, Tao2; ,
刊名MOLECULAR BIOLOGY REPORTS
出版日期2019
卷号46期号:1页码:217-223
关键词Asthma Blood gene expression Support Vector Machine Minimal Redundancy Maximal Relevance Incremental Feature Selection
ISSN号0301-4851
DOI10.1007/s11033-018-4463-6
文献子类Article
英文摘要Asthma is a complex heterogeneous disorder with hereditary tendency and the most widely used therapy is inhalation of anti-inflammatory corticosteroids. But it has systemic side effects. If the chronic inflammation can be detected in early stage, the dosage of corticosteroids will be low and the side effects can be avoided. Therefore, to discover the early stage blood biomarkers for asthma, we analyzed the gene expression profiles in the blood of 77 moderate asthma patients and 87 healthy controls. With advanced feature selection methods, minimal Redundancy Maximal Relevance and Incremental Feature Selection, we identified 31 genes, such as MYD88, ZFP36, CCR3 and CYP3A5, as the optimal asthma biomarker. The sensitivity, specificity and accuracy of the 31-gene Support Vector Machine predictor evaluated with Leave-One-Out Cross Validation were 0.870, 0.816 and 0.841, respectively. Through literature survey, many biomarker genes have asthma associated functions. Our results not only provided the easy-to-apply blood gene expression biomarkers for early detection of asthma, but also an explainable qualitative model with biological significance.
学科主题Biochemistry & Molecular Biology
WOS关键词FEATURE-SELECTION ; AIRWAY HYPERRESPONSIVENESS ; CIGARETTE-SMOKE ; LUNG-FUNCTION ; INFLAMMATION ; GLUCOCORTICOIDS ; TRISTETRAPROLIN ; IDENTIFICATION ; ASSOCIATION ; PHENOTYPES
语种英语
WOS记录号WOS:000462022300024
出版者SPRINGER
版本出版稿
源URL[http://202.127.25.144/handle/331004/608]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Zhejiang Univ, Sch Med, Dept Resp & Crit Care Med, Affiliated Hosp 2, Hangzhou 310009, Zhejiang, Peoples R China;
2.Chinese Acad Sci, Inst Hlth Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China,
推荐引用方式
GB/T 7714		 Wang, Shao-Bin,Huang, Tao,,. The early detection of asthma based on blood gene expression[J]. MOLECULAR BIOLOGY REPORTS,2019,46(1):217-223.
APA Wang, Shao-Bin,Huang, Tao,&,.(2019).The early detection of asthma based on blood gene expression.MOLECULAR BIOLOGY REPORTS,46(1),217-223.
MLA Wang, Shao-Bin,et al."The early detection of asthma based on blood gene expression".MOLECULAR BIOLOGY REPORTS 46.1(2019):217-223.

入库方式： OAI收割

来源：上海营养与健康研究所

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