Adaptive evolution of proteins in hepatitis B virus during divergence of genotypes
文献类型：期刊论文
| 作者 | Li, Shengdi1,3; Wang, Zhen3; Li, Yixue3; Ding, Guohui2,3; Li, Yixue2; , |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:-页码:1990 |
| 关键词 | p53 protein stability mouse double minute 2 homolog (MDM2) cancer stem cells colon cancer prolyl hydroxylase 3 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-017-02012-8 |
| 文献子类 | Article |
| 英文摘要 | Hepatitis B virus (HBV) is classified into several genotypes, correlated with different geographic distributions, clinical outcomes and susceptible human populations. It is crucial to investigate the evolutionary significance behind the diversification of HBV genotypes, because it improves our understanding of their pathological differences and pathogen-host interactions. Here, we performed comprehensive analysis of HBV genome sequences collected from public database. With a stringent criteria, we generated a dataset of 2992 HBV genomes from eight major genotypes. In particular, we applied a specified classification of non-synonymous and synonymous variants in overlapping regions, to distinguish joint and independent gene evolutions. We confirmed the presence of selective constraints over non-synonymous variants in consideration of overlapping regions. We then performed the McDonald-Kreitman test and revealed adaptive evolutions of non-synonymous variants during genotypic differentiation. Remarkably, we identified strong positive selection that drove the differentiation of PreS1 domain, which is an essential regulator involved in viral transmission. Our study presents novel evidences for the adaptive evolution of HBV genotypes, which suggests that these viruses evolve directionally for maintenance or improvement of successful infections. |
| 学科主题 | Science & Technology - Other Topics |
| WOS关键词 | GENOME-WIDE ASSOCIATION ; READING FRAMES ; T-CELL ; INFECTION ; VARIANTS ; SEQUENCE ; DOMAIN ; ORIGIN ; GENES ; LOCUS |
| 语种 | 英语 |
| WOS记录号 | WOS:000401406700065 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/609]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China; 2.Shanghai Ind Technol Inst, Shanghai Ctr Bioinformat Technol, 1278 Keyuan Rd, Shanghai 201203, Peoples R China, 3.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li, Shengdi,Wang, Zhen,Li, Yixue,et al. Adaptive evolution of proteins in hepatitis B virus during divergence of genotypes[J]. SCIENTIFIC REPORTS,2017,7(-):1990. |
| APA | Li, Shengdi,Wang, Zhen,Li, Yixue,Ding, Guohui,Li, Yixue,&,.(2017).Adaptive evolution of proteins in hepatitis B virus during divergence of genotypes.SCIENTIFIC REPORTS,7(-),1990. |
| MLA | Li, Shengdi,et al."Adaptive evolution of proteins in hepatitis B virus during divergence of genotypes".SCIENTIFIC REPORTS 7.-(2017):1990. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。