Listeria hijacks host mitophagy through a novel mitophagy receptor to evade killing
文献类型：期刊论文
| 作者 | Zhang, Yifan2; Yao, Yikun2; Qiu, Xiaoxu2; Wang, Guodong2; Hu, Zheng2; Chen, Siyuan2; Wu, Zhengxi2; Gao, Hanchao2; Qian, Youcun2; Yuan, Na3,4 |
| 刊名 | NATURE IMMUNOLOGY
 |
| 出版日期 | 2019 |
| 卷号 | 20期号:4页码:433-+ |
| 关键词 | ATG7 autophagy BAT whitening BTG1 glucocorticoid |
| ISSN号 | 1529-2908 |
| DOI | 10.1038/s41590-019-0324-2 |
| 文献子类 | Article |
| 英文摘要 | Cells use mitophagy to remove damaged or unwanted mitochondria to maintain homeostasis. Here we report that the intracellular bacterial pathogen Listeria monocytogenes exploits host mitophagy to evade killing. We found that L. monocytogenes induced mitophagy in macrophages through the virulence factor listeriolysin O (LLO). We discovered that NLRX1, the only Nod-like receptor (NLR) family member with a mitochondrial targeting sequence, contains an LC3-interacting region (LIR) and directly associated with LC3 through the LIR. NLRX1 and its LIR motif were essential for L. monocytogenes-induced mitophagy. NLRX1 deficiency and use of a mitophagy inhibitor both increased mitochondrial production of reactive oxygen species and thereby suppressed the survival of L. monocytogenes. Mechanistically, L. monocytogenes and LLO induced oligomerization of NLRX1 to promote binding of its LIR motif to LC3 for induction of mitophagy. Our study identifies NLRX1 as a novel mitophagy receptor and discovers a previously unappreciated strategy used by pathogens to hijack a host cell homeostasis system for their survival. |
| 学科主题 | Immunology |
| WOS关键词 | NF-KAPPA-B ; CELL-DEATH ; MONOCYTOGENES ; NLRX1 ; RECOGNITION ; AUTOPHAGY ; AUTOINHIBITION ; PATHOGENESIS ; MECHANISMS ; MITOCHONDRIA |
| 语种 | 英语 |
| WOS记录号 | WOS:000461904200014 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/611]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Zhejiang A&F Univ, Coll Anim Sci & Technol, Key Lab Appl Technol Green Ecohlth Anim Husb Zhej, Linan, Peoples R China; 2.Univ Chinese Acad Sci, Chinese Acad Sci, CAS Key Lab Tissue Microenvironm & Tumor,Shanghai, CAS Ctr Excellence Mol Cell Sci,Shanghai Inst Nut, Shanghai, Peoples R China; 3.Soochow Univ, Sch Med, Hematol Ctr Cyrus Tang Med Inst,Key Lab Stem Cell, Jiangsu Inst Hematol,Collaborat Innovat Ctr Hemat, Suzhou, Peoples R China; 4.Soochow Univ, Sch Med, Chinese Minist Sci & Technol, State Key Lab Radiat Med & Radioprotect, Suzhou, Peoples R China; 5.Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada; 6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Zhang, Yifan,Yao, Yikun,Qiu, Xiaoxu,et al. Listeria hijacks host mitophagy through a novel mitophagy receptor to evade killing[J]. NATURE IMMUNOLOGY,2019,20(4):433-+. |
| APA | Zhang, Yifan.,Yao, Yikun.,Qiu, Xiaoxu.,Wang, Guodong.,Hu, Zheng.,...&,.(2019).Listeria hijacks host mitophagy through a novel mitophagy receptor to evade killing.NATURE IMMUNOLOGY,20(4),433-+. |
| MLA | Zhang, Yifan,et al."Listeria hijacks host mitophagy through a novel mitophagy receptor to evade killing".NATURE IMMUNOLOGY 20.4(2019):433-+. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。