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MLKL attenuates colon inflammation and colitis-tumorigenesis via suppression of inflammatory responses

文献类型：期刊论文

作者Zhao, Qun1,3,4; Li, Ming3; Liu, YongBo3; Han, YaMei3; Zhang, XiXi3; Li, Xiao Ming3; Wu, XiaoXia3; Fang, Jing3; Zhang, Haibing3; Yu, XianJun1,4
刊名CANCER LETTERS
出版日期2019
卷号459期号:-页码:100-111
关键词MLKL Necroptosis Dendritic cells Colitis-associated tumorigenesis
ISSN号0304-3835
DOI10.1016/j.canlet.2019.05.034
文献子类Article
英文摘要The mixed lineage kinase domain-like protein (MLKL) has emerged as a critical mediator of necroptosis, which results in the release of cellular damage-associated molecular patterns (DAMPs). However, its physiological role in regulating inflammation is not fully understood. We herein showed that Mlkl(-/-) mice were highly susceptible to colitis and colitis-associated tumorigenesis (CAT), which was associated with massive leukocyte infiltration and increased inflammatory responses. Moreover, we used bone marrow transplantation to reveal that MLKL in inflammatory cells is crucial for its role on colitis. Intestinal mucosal tissue and polyps isolated from Mlkl(-/-) mice exhibited increased ERK activation and elevated expression of genes associated with inflammation and cancer. Mechanistically, enhanced inflammation in Mlkl(-/-) mice was due to MEK/ERK activation particularly in dendritic cells (DCs). Our results demonstrate the role of MLKL in maintaining intestinal homeostasis and protecting against colitis and tumorigenesis.
学科主题Oncology
WOS关键词TUMOR-NECROSIS-FACTOR ; MIXED LINEAGE KINASE ; RECEPTOR-INTERACTING PROTEIN ; MEDIATES NECROPTOSIS ; PSEUDOKINASE MLKL ; DOMAIN-LIKE ; PROGRAMMED NECROSIS ; CANCER STATISTICS ; INDUCED CYTOKINE ; P38 MAPK
语种英语
WOS记录号WOS:000480670800010
出版者ELSEVIER IRELAND LTD
版本出版稿
源URL[http://202.127.25.144/handle/331004/613]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Hubei Univ Med, Sch Basic Med Sci, Lab Inflammat & Mol Pharmacol, Shiyan 442000, Peoples R China;
2.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci,Shanghai Inst Nutr & Hlth, CAS Key Lab Tissue Microenvironm & Tumor,CAS Ctr, Shanghai 200031, Peoples R China,
3.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Key Lab Nutr Metab & Food Safety,Shanghai Ins, Shanghai 200031, Peoples R China;
4.Hubei Univ Med, Biomed Res Inst, Shiyan 442000, Peoples R China;
推荐引用方式
GB/T 7714		 Zhao, Qun,Li, Ming,Liu, YongBo,et al. MLKL attenuates colon inflammation and colitis-tumorigenesis via suppression of inflammatory responses[J]. CANCER LETTERS,2019,459(-):100-111.
APA Zhao, Qun.,Li, Ming.,Liu, YongBo.,Han, YaMei.,Zhang, XiXi.,...&,.(2019).MLKL attenuates colon inflammation and colitis-tumorigenesis via suppression of inflammatory responses.CANCER LETTERS,459(-),100-111.
MLA Zhao, Qun,et al."MLKL attenuates colon inflammation and colitis-tumorigenesis via suppression of inflammatory responses".CANCER LETTERS 459.-(2019):100-111.

入库方式： OAI收割

来源：上海营养与健康研究所

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