Extracellular vesicles in the tumor microenvironment: old stories, but new tales
文献类型：期刊论文
| 作者 | Han, Liu4; Sun, Yu4; Lam, Eric W. -F.2; Sun, Yu1,3; , |
| 刊名 | MOLECULAR CANCER
 |
| 出版日期 | 2019 |
| 卷号 | 18期号:-页码:59 |
| 关键词 | Extracellular vesicles Tumor microenvironment Cancer biology Therapeutic target Clinical biomarker |
| ISSN号 | 1476-4598 |
| DOI | 10.1186/s12943-019-0980-8 |
| 文献子类 | Review |
| 英文摘要 | Mammalian cells synthesize and release heterogeneous extracellular vesicles (EVs) which can be generally recognized as subclasses including exosomes, microvesicles (MVs), and apoptotic bodies (ABs), each differing in their biogenesis, composition and biological functions from others. EVs can originate from normal or cancer cells, transfer bioactive cargoes to both adjacent and distant sites, and orchestrate multiple key pathophysiological events such as carcinogenesis and malignant progression. Emerging as key messengers that mediate intercellular communications, EVs are being paid substantial attention in various disciplines including but not limited to cancer biology and immunology. Increasing lines of research advances have revealed the critical role of EVs in the establishment and maintenance of the tumor microenvironment (TME), including sustaining cell proliferation, evading growth suppression, resisting cell death, acquiring genomic instability and reprogramming stromal cell lineages, together contributing to the generation of a functionally remodeled TME. In this article, we present updates on major topics that document how EVs are implicated in proliferative expansion of cancer cells, promotion of drug resistance, reprogramming of metabolic activity, enhancement of metastatic potential, induction of angiogenesis, and escape from immune surveillance. Appropriate and insightful understanding of EVs and their contribution to cancer progression can lead to new avenues in the prevention, diagnosis and treatment of human malignancies in future medicine. |
| 学科主题 | Biochemistry & Molecular Biology ; Oncology |
| WOS关键词 | CANCER-CELLS ; IN-VITRO ; TRANSFERRIN RECEPTOR ; CISPLATIN RESISTANCE ; HORIZONTAL TRANSFER ; COLORECTAL-CANCER ; EMERGING ROLE ; EXOSOMES ; PROMOTE ; MICROVESICLES |
| 语种 | 英语 |
| WOS记录号 | WOS:000462941900019 |
| 出版者 | BMC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/616]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Washington, Dept Med, Seattle, WA 98195 USA; 2.Imperial Coll London, Dept Surg & Canc, London W12 0NN, England; 3.Univ Washington, VAPSHCS, Seattle, WA 98195 USA, 4.Univ Chinese Acad Sci, Chinese Acad Sci, CAS Key Lab Tissue Microenvironm & Tumor, Shanghai Inst Nutr & Hlth,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Han, Liu,Sun, Yu,Lam, Eric W. -F.,et al. Extracellular vesicles in the tumor microenvironment: old stories, but new tales[J]. MOLECULAR CANCER,2019,18(-):59. |
| APA | Han, Liu,Sun, Yu,Lam, Eric W. -F.,Sun, Yu,&,.(2019).Extracellular vesicles in the tumor microenvironment: old stories, but new tales.MOLECULAR CANCER,18(-),59. |
| MLA | Han, Liu,et al."Extracellular vesicles in the tumor microenvironment: old stories, but new tales".MOLECULAR CANCER 18.-(2019):59. |
入库方式： OAI收割
来源：上海营养与健康研究所
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